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APPLICATION OF MONOCLONAL ANTIBODY FOR THE NEW TREATMENT AND DIAGNOSIS OF DIGESTIVE CANCER.

APPLICATION OF MONOCLONAL ANTIBODY FOR THE NEW TREATMENT AND DIAGNOSIS OF DIGESTIVE CANCER.
单克隆抗体在消化道癌新治疗和诊断中的应用。
批准号：
07457277
负责人：
TAKAHASHI Toshio
金额：
$4.61万
依托单位：
KYOTO PREFECTURAL UNIVERSITY OF MEDICINE
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1995
资助国家：
日本
项目状态：
已结题
起止时间：
1995 至 1997
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457277/
关键词：
DIGESTIVE CANCERMONOCLONAL ANTIBODYCHIMERIC ANTIBODYMICRO-FERRITE外科手術画像診断化学療法磁性鉄転移神経温存イメージング

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中文摘要
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英文摘要
Huma/mouse chmeric antibody had been developed and anti-cancer drug neocarzinostatin could be bound with Fab fragment of chiemric antibody without loosing both anticancer and antibody activites. Clinical phase 1 study had been carried out and no seriouse adverse effects had been observed up to 40,000 units of immunoconojugates. The production of human anti-mouse antibody (HAMA) had been strongly suppressed in patients receiving chimeric antibody compared with patients receiving mouse immunocojugates.Fine ferromagnetics had been successfully conojugated with antibody. The stability and capacity of the cojugates to bind with target cancer cell had been well preserved. The imaging of tumor tissue in experimental animal suggested its usefullness in MRI imaging in vivo. This new ferromagnetic immunoconjugate could be applied for ferro-immuno-guided surgery in the near future.
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C.Sakakura: "Overexpression of Bax Sensitizes Breast Cancer MCF-7 Cells to Cisplatin and Etoposide" Surgery Today. 27. 676-679 (1997)
C.Sakakura：“Bax 的过度表达使乳腺癌 MCF-7 细胞对顺铂和依托泊苷敏感”，今日手术。
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C.Sakakura: "Increased Apoptosis Rate by Hyperthermochemo radiotheraphy for Advanced Rectal Cancers" Surgery Today. 27. 773-776 (1997)
C.Sakakura：“通过热化疗放疗提高晚期直肠癌的细胞凋亡率”《今日手术》。
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E.Otsuji, T.Yamaguchi, H.Tsuruta, Y.Yata, H.Nishi, K.Okamoto, K.Taniguchi, M.Kato, T.Kotani, K.Kitamura, T.Takahashi: "Applicability of monoclonal antibody fab fragments as a carrier of neocarzinostatin in targeting chemotherapy" J.Surg.Oncol.61. 149-154
E.Otsuji、T.Yamaguchi、H.Tsuruta、Y.Yata、H.Nishi、K.Okamoto、K.Taniguchi、M.Kato、T.Kotani、K.Kitamura、T.Takahashi：“单克隆抗体工厂的适用性
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E.Otsuji, T.Yamaguchi, H.Tsuruta, Y.Yata, H.Nishi, K.Okamoto, K.Taniguchi, M.Kato, T.Kotani, K.Kitamura, T.Takahashi: "Effects of neocarzinostain-chimeric Fab conjugates on the growth of human pancreatic carcinoma xenografts" Brit.J.Cancer. 73. 1178-1182
E.Otsuji、T.Yamaguchi、H.Tsuruta、Y.Yata、H.Nishi、K.Okamoto、K.Taniguchi、M.Kato、T.Kotani、K.Kitamura、T.Takahashi：“新癌菌染色剂嵌合的效果
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共 89 条
    Surface X-ray diffraction studies of ultrathin films and their structural changes from bulk crystals
    • 批准号：
      16H03866
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $10.73万
    • 财政年份：
      2016
    • 负责人：
      TAKAHASHI Toshio
    • 依托单位：
      Tokyo Gakugei University
    Analysis of precise electron density of topological insulator thin films by applying direct methods to surface X-ray diffraction
    Development and application of a holographic method for the analysis of interfaces with atomic resolution using X-ray CTR scattering
    • 批准号：
      22360018
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $12.4万
    • 财政年份：
      2010
    • 负责人：
      TAKAHASHI Toshio
    • 依托单位：
      The University of Tokyo
    Study on the one-dimensional structure of metals on semiconductor surfaces and buried interfaces
    • 批准号：
      16360017
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $8.96万
    • 财政年份：
      2004
    • 负责人：
      TAKAHASHI Toshio
    • 依托单位：
      The University of Tokyo
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