Common roles of macrophage proliferation and polarization in type 2 diabetes and atherosclerosis.

糖尿病模型db/db胰岛炎性M1巨噬细胞浸润明显增加，提示M1巨噬细胞参与了2型糖尿病B细胞功能障碍。我们建立了清道夫受体启动子调控下的p27基因转基因小鼠，即巨噬细胞特异性增殖抑制小鼠。然而，该突变小鼠的雄性和雌性都是不育的。转基因小鼠骨髓源性巨噬细胞p27 mRNA表达明显增加，其增殖受到抑制。巨噬细胞p27表达在不孕症中的作用将是另一个有待进一步研究的课题。

Inflammatory M1 macrophage infiltration into pancreatic isletsin diabetic model db/db was significantly increased, which suggested the implication of M1 macrophage in b cell dysfunction in type 2 diabetes. We generated the transgenic mouse containing p27 cDNA under the control of scavenger receptor promoter, which is macrophage-specific proliferation restricted mouse. However both male and female of this mutant mouse were infertile. The p27 mRNA expression was significantly increased in bone marrow-derived macrophage from Tg mice, and the proliferation of these macrophages were restricted. The effect of p27 expression in macrophage on infertility will be another project to be studied farther.