Common roles of macrophage proliferation and polarization in type 2 diabetes and atherosclerosis.

巨噬细胞增殖和极化在 2 型糖尿病和动脉粥样硬化中的常见作用。

• 批准号: 21890197
• 负责人: SENOKUCHI Takafumi
• 金额: $ 1.66万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21890197/
• 关键词: 2型糖尿病; 動脈硬化; マクロファージ; 動脈硬化症; マクロファージ増殖

Inflammatory M1 macrophage infiltration into pancreatic isletsin diabetic model db/db was significantly increased, which suggested the implication of M1 macrophage in b cell dysfunction in type 2 diabetes. We generated the transgenic mouse containing p27 cDNA under the control of scavenger receptor promoter, which is macrophage-specific proliferation restricted mouse. However both male and female of this mutant mouse were infertile. The p27 mRNA expression was significantly increased in bone marrow-derived macrophage from Tg mice, and the proliferation of these macrophages were restricted. The effect of p27 expression in macrophage on infertility will be another project to be studied farther.

糖尿病模型中炎性M1巨噬细胞浸润胰岛的db/db显著增加，提示M1巨噬细胞参与2型糖尿病b细胞功能障碍。我们在清道夫受体启动子的控制下，培育了含有p27 cDNA的巨噬细胞特异性增殖受限小鼠。然而，该突变小鼠的雄性和雌性都是不育的。Tg小鼠骨髓源性巨噬细胞p27 mRNA表达显著升高，巨噬细胞增殖受到抑制。巨噬细胞中p27的表达对不孕症的影响将是另一个需要进一步研究的项目。