Mood disorders associated with latent herpes virus infection in the brain.

在本研究中，我们旨在阐明HHV-6(SITH)-1中间阶段转录本编码的小蛋白与情绪障碍之间的联系。SITS-1显著上调细胞内钙离子水平。钙水平的增加通常被认为是情绪障碍的一个重要因素。当我们使Sith-1在小鼠脑胶质细胞中表达时，小鼠表现出躁狂样行为和抑郁样行为。这些结果表明Sith-1与情绪障碍的发生有关。

In the present study, we have aimed to clarify the connection between the Small protein encoded by the Intermediate stage Transcript of HHV-6 (SITH)-1 and mood disorders. SITH-1 significantly up-regulated the intracellular calcium levels. An increase in calcium levels is generally thought to be an important factor in mood disorders. When we caused SITH-1 to be expressed in mouse brain glial cells, the mouse showed manic-like behavior and depressive-like behavior. These results suggest that SITH-1 is involved in the onset of mood disorders.