Prevortion of neural cell death and decveare of home mineral density after spinal cord injury

脊髓损伤后预防神经细胞死亡和降低体内矿物质密度

• 批准号: 14571383
• 负责人: MORI Satoshi
• 金额: $ 1.92万
• 依托单位: Kagawa University Faculty of Medecine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571383/
• 关键词: spinal cord injury; regeneration; radial glia; systemic hypothermia; apoptosis; 放射状グリア; 3CB2抗原; 軟膜下アストロサイト; アポトーシス細胞死; 放射状グリア細胞; 神経再生修復; GFAP

We investigated that prevention of neural cell death and decrease of home mineral density after spinal cord injury (SCI). Systemic hypothermia shows a neuroprotective effect after SCI by attenuating post-traumatic apoptotic cell death.And, we analyzed mechanism of neural regenerution and repuir after SCI. Our study demonstrated the re-emergence of radial glia after SCI in adult mamnals. Radial glia derived from subpial astrocyte may play an important role in neural repair and regeneration after SCI.

我们研究了脊髓损伤（SCI）后神经细胞死亡的预防和体内矿物质密度的降低。全身低温通过减轻创伤后细胞凋亡而显示出 SCI 后的神经保护作用。并且，我们分析了 SCI 后神经再生和恢复的机制。我们的研究证明了成年哺乳动物脊髓损伤后放射状胶质细胞的重新出现。软膜下星形胶质细胞来源的放射状胶质细胞可能在 SCI 后的神经修复和再生中发挥重要作用。

项目成果

Temporal progressive antigen expression in radial glia after contusive spinal cord injury in adult rats

• DOI: 10.1002/glia.10203
• 发表时间: 2003-04
• 期刊: Glia
• 影响因子: 6.2
• 作者: S. Shibuya;O. Miyamoto;T. Itano;S. Mori;H. Norimatsu

Post-traumatic moderate systemic hypothermia reduces TUNEL positive cells following spinal cord injury in rat

• DOI: 10.1038/sj.sc.3101516
• 发表时间: 2004
• 期刊: Spinal Cord
• 影响因子: 2.2
• 作者: S. Shibuya;O. Miyamoto;N. Janjua;T. Itano;S. Mori;H. Norimatsu

Shibuya S: "Embryonic intermediate filament, nestin, expression following traumatic spinal cord injury in adult rats."Neuroscience. 114(4). 905-916 (2002)

Shibuya S：“胚胎中间丝，巢蛋白，成年大鼠脊髓创伤后的表达。”神经科学。

Shibuya S: "Post-traumatic moderate systemic hypothermia reduces TUNELpositive cells following spinal cord injury in rat."Spinal Cord. 42(1). 29-34 (2004)

Shibuya S：“创伤后中度全身低温会减少大鼠脊髓损伤后的 TUNEL 阳性细胞。”脊髓。

Shibuya S: "Temporal progressive antigen expression in radial glia after contusive spinal cord injury in adult rats."Glia. 42(2). 172-183 (2003)

Shibuya S：“成年大鼠挫伤性脊髓损伤后放射状胶质细胞中的时间渐进性抗原表达。”神经胶质细胞。