Abnormal differentiation of tumor cells and tyrosine kinase regulation

肿瘤细胞异常分化与酪氨酸激酶调控

• 批准号: 17014069
• 负责人: YOSHIMURA Akihiko
• 金额: $ 38.34万
• 依托单位: Keio University (2008-2009)Kyushu University (2005-2007)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17014069/
• 关键词: サイトカイン; シグナル伝達; チロシンキナーゼ; 転写因子; STAT; 炎症; Ras; ERK; 家族性変異; 発がん; Spred; 神経繊維腫I型; SOCS; Sred; 肝炎; 肝がん; チロシンりん酸化; インターフェロン

Inflammatory cells are involved in tumor growth and development through various inflammatory mediators. Inflammatory cytokines activate the NF-kB and JAK/STAT pathways. We have investigated the function of SOCS family and Spred family proteins which regulate cytokine signaling, on tumorigenesi. In model mice lacking SOCS1 or SOCS3 genes, we found that carcinogen-induced tumorigensis was promoted. In human hepatocellular carcinoma, SOCS1 and SOCS3 gene expression was silenced. We also found that human SPRED1 is responsible for neurofibromatosis type I like disease.

炎症细胞通过各种炎症介质参与肿瘤的生长和发展。炎性细胞因子激活NF-kB和JAK/STAT通路。我们研究了SOCS家族和Spred家族调节细胞因子信号传导的蛋白在肿瘤发生中的作用。在缺乏SOCS1或SOCS3基因的模型小鼠中，我们发现致癌物诱导的肿瘤发生被促进。在人肝细胞癌中，SOCS1和SOCS3基因表达被沉默。我们还发现，人SPRED 1是负责神经纤维瘤病I型样疾病。

项目成果

Rudensky AY. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein.

鲁登斯基 AY.

• 发表时间: 2009
• 期刊: Immunity 30(1)
• 作者: Lu LF;Thai TH;Calado DP;Chaudhry A;Kubo M;Tanaka K;Loeb GB;Lee H;Yoshimura A;Rajewsky K
• 通讯作者: Rajewsky K

SOCS is a molecular link between inflammation and cancer development. International symposium of infection-associated cancers

SOCS 是炎症与癌症发展之间的分子联系。

• 发表时间: 2010
• 作者: Hanada T;Tanaka K;Yoshimura A;et al.;Akihiko Yoshimura
• 通讯作者: Akihiko Yoshimura

Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokin signaling 3-deficient dendritic cells.

Foxp3 阳性调节性 T 细胞的选择性扩增和细胞因子信号传导 3 缺陷树突状细胞抑制剂的免疫抑制。

• 发表时间: 2007
• 期刊: J Immunol. 179
• 作者: Matsumura;Y・Wyss-Coray;T・Sato;K・Yoshimura;A;et. al.
• 通讯作者: et. al.

Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation

• DOI: 10.1111/j.1349-7006.2009.01098.x
• 发表时间: 2009-04-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Hashimoto, Masayuki;Ayada, Toranoshin;Yoshimura, Akihiko
• 通讯作者: Yoshimura, Akihiko

Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1.

T辅助细胞中SOCS3的丧失导致免疫反应降低，白介素10并转化生长因子-Beta 1。

• DOI: 10.1084/jem.20052333
• 发表时间: 2006-04-17
• 期刊: The Journal of experimental medicine
• 作者: Kinjyo I;Inoue H;Hamano S;Fukuyama S;Yoshimura T;Koga K;Takaki H;Himeno K;Takaesu G;Kobayashi T;Yoshimura A
• 通讯作者: Yoshimura A