Molecular Mechanism of Regulation of the Cytokine Signal and Immunity

细胞因子在调节先天免疫和适应性免疫中起重要作用。我们利用基因工程小鼠研究了SOCS家族和Spred/Sprouty家族蛋白调节细胞因子信号的功能。我们发现SOCS 1和SOCS 3通过调节STAT转录因子来调节辅助性T细胞的分化，包括Th 17和Tcl 2。我们还发现，人SPRED 1是负责神经纤维瘤病I型样疾病。此外，我们发现了一个新的机制，cAMP介导的TLR信号抑制通过c-fos。我们还发现Smad 2/3对于TGF-β的免疫抑制是必不可少的。

Cytokines play essential roles in regulation of innate and adaptive immunity. We have investigated the function of SOCS family and Spred/Sprouty family proteins which regulate cytokine signaling, by using genetically engineered mice. We found that SOCS1 and SOCS3 regulate helper T cell differentiation incuding Th17 and Tregs by modulating STAT transcription factors. We also found that human SPRED1 is responsible for neurofibromatosis type I like disease. Furthermore we discovered a novel mechanism of cAMP-mediated TLR signaling suppression through c-fos. We also found that Smad2/3 is essential for immunosuppression by TGF-beta.