Molecular Mechanism of Regulation of the Cytokine Signal and Immunity

细胞因子在调节先天免疫和适应性免疫中发挥重要作用。我们利用基因工程小鼠研究了SOCS家族和Spred/Sprouty家族蛋白调控细胞因子信号的功能。我们发现SOCS1和SOCS3通过调节STAT转录因子调控Th17和Tregs等辅助性T细胞分化。我们还发现人类SPRED1与I型神经纤维瘤病相关。此外，我们还发现了camp通过c-fos介导的TLR信号抑制的新机制。我们还发现Smad2/3对于tgf - β的免疫抑制至关重要。

Cytokines play essential roles in regulation of innate and adaptive immunity. We have investigated the function of SOCS family and Spred/Sprouty family proteins which regulate cytokine signaling, by using genetically engineered mice. We found that SOCS1 and SOCS3 regulate helper T cell differentiation incuding Th17 and Tregs by modulating STAT transcription factors. We also found that human SPRED1 is responsible for neurofibromatosis type I like disease. Furthermore we discovered a novel mechanism of cAMP-mediated TLR signaling suppression through c-fos. We also found that Smad2/3 is essential for immunosuppression by TGF-beta.