An informatics approach to the systematic understanding of a model disease

系统理解模型疾病的信息学方法

• 批准号: 17019065
• 负责人: GOJOBORI Takashi
• 金额: $ 60.29万
• 依托单位: National Institute of Genetics
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17019065/
• 关键词: 疾患情報; 脳・神経系; 情報生物学; データベース; 疾患情報モデル; ゲノム; 表現型; アノテーション

We developed three-dimensional brain databases for human, mouse, and tunicate, which constitute the platform for constructing disease-information models of neuronal diseases. We also mirrored the three-dimensional mouse brain database of Paul Allen Brain Institute of the United States, and compared gene expression patterns in human and mouse brains. In particular, we clarified the protein-protein interaction network of the proteins associated with the Altzheimer's disease.

建立了人、鼠、被囊动物的三维脑数据库，为构建神经元疾病的疾病信息模型提供了平台。我们还镜像了美国保罗·艾伦大脑研究所的三维小鼠大脑数据库，并比较了人类和小鼠大脑中的基因表达模式。特别是，我们澄清了与阿尔茨海默病相关的蛋白质的蛋白质-蛋白质相互作用网络。

项目成果

Big data: The future of biocuration.

• DOI: 10.1038/455047a
• 发表时间: 2008-09-04
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Howe, Doug;Costanzo, Maria;Fey, Petra;Gojobori, Takashi;Hannick, Linda;Hide, Winston;Hill, David P.;Kania, Renate;Schaeffer, Mary;St Pierre, Susan;Twigger, Simon;White, Owen;Rhee, Seung Yon
• 通讯作者: Rhee, Seung Yon

DDBJ dealing with mass data produced by the second generation sequencer.

• DOI: 10.1093/nar/gkn724
• 发表时间: 2009-01
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Sugawara H;Ikeo K;Fukuchi S;Gojobori T;Tateno Y
• 通讯作者: Tateno Y

H-InvDB in 2009: extended database and data mining resources for human genes and transcripts.

• DOI: 10.1093/nar/gkp1020
• 发表时间: 2010-01
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Yamasaki C;Murakami K;Takeda J;Sato Y;Noda A;Sakate R;Habara T;Nakaoka H;Todokoro F;Matsuya A;Imanishi T;Gojobori T
• 通讯作者: Gojobori T

『月刊「公明」』3

《公明月刊》3

• 发表时间: 2009
• 作者: 五條堀孝;金城その子;Jose C. Clemente;池尾一穂;五條堀孝;Nakajima T;五條堀孝;五條堀孝;Yamagata T;林崎良英;Nakayama Y;五條堀孝
• 通讯作者: 五條堀孝

Comparative study of flux redistribution of metabolic pathway in glutamate production by two coryneform bacteria.

• DOI: 10.1016/j.ymben.2004.10.001
• 发表时间: 2005-03
• 期刊: Metabolic engineering
• 影响因子: 8.4
• 作者: Tomokazu Shirai;Akinori Nakato;N. Izutani;K. Nagahisa;S. Shioya;E. Kimura;Y. Kawarabayasi;A. Yamagishi;T. Gojobori;H. Shimizu