Structural and molecular bases for development and maturation of competitive synaptic wiring

竞争性突触布线的发展和成熟的结构和分子基础

• 批准号: 17023001
• 负责人: WATANABE Masahiko
• 金额: $ 68.42万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17023001/
• 关键词: 小脳; シナプス; グルタミン酸; 発達; 遺伝子改変動物; グルタミン酸トランスポーター; 登上線維; mGluR1; プルキンエ細胞; グルタミン酸受容体; セレベリン; GluRd2; シナプス形成; 遺伝子ノックアウトマウス

An enormous number of homotypic and heterotypic inputs innervate given neurons, and establish functional neural circuits through their competition. In this study, I undertook cellular and molecular mechanisms underlying the competitive circuit development in the cerebellum, a center of motor learning and coordination. I have identified that glutamate receptor GluD2 on Purkinje cells and Cbln1 released from granule cells coordinately regulate the formation and maintenance of parallel fiber synapses, and the establishment and maintenance of climbing fiber mono-innervation.

大量的同型和异型输入支配着给定的神经元，并通过它们的竞争建立起功能性的神经回路。在这项研究中，我研究了小脑竞争回路发展的细胞和分子机制，小脑是运动学习和协调的中心。我发现浦肯野细胞上的谷氨酸受体GluD2和颗粒细胞释放的Cbln1协同调节平行纤维突触的形成和维持，以及攀爬纤维单神经支配的建立和维持。

项目成果

Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRδ2

• DOI: 10.1523/jneurosci.2553-07.2008
• 发表时间: 2008-02-06
• 期刊: JOURNAL OF NEUROSCIENCE
• 影响因子: 5.3
• 作者: Kakegawa, Wataru;Miyazaki, Taisuke;Yuzaki, Michisuke
• 通讯作者: Yuzaki, Michisuke

Evidence against GABA release from glutamatergic mossy fiber terminals in the developing hippocampus

发育中的海马体中谷氨酸能苔藓纤维末端释放 GABA 的证据

• 发表时间: 2007
• 期刊: Journal of Neuroscience 27
• 作者: Uchigashima;M. ;et. al.
• 通讯作者: et. al.

Distribution of type 1 cannabinoid receptor (CB1)‐immunoreactive axons in the mouse hypothalamus

• DOI: 10.1002/cne.21383
• 发表时间: 2007-04
• 期刊: Journal of Comparative Neurology
• 影响因子: 2.5
• 作者: G. Wittmann;L. Deli;I. Kalló;E. Hrabovszky;Masahiko Watanabe;Zsolt Liposits;C. Fekete

Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity

• DOI: 10.1038/sj.emboj.7601639
• 发表时间: 2007-04-04
• 期刊: EMBO JOURNAL
• 影响因子: 11.4
• 作者: Kakizawa, Sho;Kishimoto, Yasushi;Takeshima, Hiroshi
• 通讯作者: Takeshima, Hiroshi

Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum

• DOI: 10.1523/jneurosci.0448-07.2007
• 发表时间: 2007-04-04
• 期刊: JOURNAL OF NEUROSCIENCE
• 影响因子: 5.3
• 作者: Uchigashima, Motokazu;Narushima, Madoka;Watanabe, Masahiko
• 通讯作者: Watanabe, Masahiko