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Structural and molecular bases for development and maturation of competitive synaptic wiring

Structural and molecular bases for development and maturation of competitive synaptic wiring
竞争性突触布线的发展和成熟的结构和分子基础
批准号:
17023001
负责人:
WATANABE Masahiko
金额:
$68.42万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009

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中文摘要
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英文摘要
An enormous number of homotypic and heterotypic inputs innervate given neurons, and establish functional neural circuits through their competition. In this study, I undertook cellular and molecular mechanisms underlying the competitive circuit development in the cerebellum, a center of motor learning and coordination. I have identified that glutamate receptor GluD2 on Purkinje cells and Cbln1 released from granule cells coordinately regulate the formation and maintenance of parallel fiber synapses, and the establishment and maintenance of climbing fiber mono-innervation.
期刊论文(247)
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会议论文
DOI: 10.1523/jneurosci.2553-07.2008
发表时间: 2008-02-06
期刊: JOURNAL OF NEUROSCIENCE
影响因子: 5.3
作者: [Kakegawa, Wataru, Miyazaki, Taisuke, Yuzaki, Michisuke]
通讯作者: Yuzaki, Michisuke
Evidence against GABA release from glutamatergic mossy fiber terminals in the developing hippocampus
发育中的海马体中谷氨酸能苔藓纤维末端释放 GABA 的证据
DOI: --
发表时间: 2007
期刊: Journal of Neuroscience 27
影响因子: --
作者: [Uchigashima, M. , et. al.]
通讯作者: et. al.
DOI: 10.1002/cne.21383
发表时间: 2007-04
期刊: Journal of Comparative Neurology
影响因子: 2.5
作者: [G. Wittmann;L. Deli;I. Kalló;E. Hrabovszky;Masahiko Watanabe;Zsolt Liposits;C. Fekete]
通讯作者: G. Wittmann;L. Deli;I. Kalló;E. Hrabovszky;Masahiko Watanabe;Zsolt Liposits;C. Fekete
DOI: 10.1038/sj.emboj.7601639
发表时间: 2007-04-04
期刊: EMBO JOURNAL
影响因子: 11.4
作者: [Kakizawa, Sho, Kishimoto, Yasushi, Takeshima, Hiroshi]
通讯作者: Takeshima, Hiroshi
188
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    • 批准号:
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    • 项目类别:
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    • 资助金额:
      $3.0万
    • 财政年份:
      2016
    • 负责人:
      WATANABE Masahiko
    • 依托单位:
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    • 资助金额:
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    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
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    • 批准号:
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    • 项目类别:
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    • 资助金额:
      $3.0万
    • 财政年份:
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    • 负责人:
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