FORENSIC PATHOLOGICAL STUDY ON PROTEINS AND GENES INDUCED BY STRESS OR ISCHEMIA

点击翻译按钮获取中文摘要

1) We found that nitric oxide protects myocardium against reperfusion injury through activation of PKC isoforms in the per fused rat heart, We also found that PKC-δ or ε isoform is involved in the protection conferred by ischemic preconditioning (that mimics the protective effect of angina against subsequent infarction) against myocardial injury by ischemia- reperfusion. We showed that hypoxia-reoxygenation activates PKC-ζ-MAP kinase- C-fos cascade that suppresses cell death due to apoptosis in myogenic cells. Two small heat shock proteins, HSP27 and MKBP translocates to the myofibrils during myocardial ischemia, while they are upregulated transiently after the birth. We also found that the genes of small HSP are under the control of a protease system proteasome and identified the transcription factor.2) Emotional stress evoked in the rat by immobilization actuvates MAP kinase- c-fos cascade.