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ショウジヨウバエ複眼形成系を利用した細胞増殖・分化、細胞死を制御する遺伝子の同定

使用果蝇复眼形成系统鉴定控制细胞增殖、分化和细胞死亡的基因

基本信息

批准号：
11139209
负责人：
三輪正直
金额：
$ 1.28万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas (A)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至无数据
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11139209/
关键词：
DNA修復 PARP ショウジョウバエ RhoA 細胞骨格

项目摘要

細胞死、細胞増殖・分化の調節機構を解明する目的で、DNA修復に関わるポリADP-リボース合成酵素(PARP)を中心に調べている。1)発生における細胞増殖・細胞死・細胞周期の解析に非常に有用であるショウジョウバエの系で、複眼原器特異的PARP過剰発現個体では、成虫複眼において組織極性異常・細胞の形態異常を伴う複眼形成異常が認められた。また、PARPの全身発現個体を作り調べたところ、複眼・羽・足・背中などの組織において同様に組織極性の異常を認めた。2)PARP過剰発現による形質は、組織極性遺伝子の変異・過剰発現によるものと酷似していた。組織極性因子である低分子量GTP結合タンパク質RhoAのショウジョウバエ相同因子の過剰発現の影響が、PARP過剰発現により抑制されることを明らかにし、PARPとRhoAとの機能的相互作用の可能性を示した。

Cell death, cell differentiation, cell differentiation, DNA repair, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation, cell death, cell differentiation, cell differentiation 1) it is very useful to analyze the cell cycle of cell death cell in human. It is very useful to analyze the cell cycle of cell death cell. It is very useful to analyze the cell cycle of cell death cell. It is very useful to analyze the cell cycle of cell death cell. It is very useful to analyze the cell cycle of cell death cell. It is very useful to study the cell cycle analysis of cell death cell death cell cycle analysis. It is very useful to analyze the cell cycle of cell death cell. The whole body of the baby, the PARP, the body, the back, the back and the back. 2) PARP filters show signs of disorder, and organizational health problems are similar to those of patients. Tissue factor: the combination of low molecular weight GTP and low molecular weight GTP, the same factor, the inhibition effect, and the possibility of interaction between PARP and RhoA were demonstrated.