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Development of a new instrument for non-invasive measurements of tissue (muscle) blood flow by near-infrared spectoroscopy.

开发一种通过近红外光谱法无创测量组织（肌肉）血流的新仪器。

基本信息

批准号：
11670063
负责人：
SAKAI Akio
金额：
$ 2.3万
依托单位：
Shinshu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670063/
关键词：
PSA-III-N NIRS Venous Occlusion Method muscle blood flow ヘモグロビン量 PSAIIIIV

项目摘要

We have developed a method of non-invasive and continuous measurements of oxygen saturation (St O_2) and absolute volumes of hemoglobin (Hb vol) using near-infrared spectroscopy (NIRS). An instrument (PSA-III N) has been designed for the use of this method so that the tissue surface can be irradiated successively with infrared light of three wavelengths, and the scattered light from the tissue can be measured on the tissue surface at a point a certain distance away from the irradiated site. St O_2 and absolute values of Hb vol in tissues can be non-invasively determined from the measured absorbance using equations derived from Lambert-beer's law. Values of Hb vol from PSA-III N show the absolute values of Hb vol or blood vol in tissue. So, we applied to measure muscle-blood flow using PSA-III N.In generally, to measure the tissue-blood flow is doing by method of venous occlusion (60mmHg) plethysmography. So, we measured the tissue-blood flow using PSA-III N by venous occlusion (60mmHg). And we compared the values between from the usual method of venous occlusion (60mmHg) plethysmography and from the our PSA-III N with venous occlusion (60mmHg). 8 male subjects were used in this experiment. Each subject was conducted a graded handgrip exercise. During the exercise, muscle blood flow were measured by two methods , i.e., the usual method of venous occlusion (60mmHg) plethysmography and the method of PSA-III N with venous occlusion (60mmHg).We got total 203 points of muscle blood flow with the two methods. And a significant correlation (r=0.60, p<0.01) was observed between values from two methods.From these results, we concluded that the instrument (PSA-III N) offers a means of measuring muscle blood flow, and may be very useful in basic and clinical medicine.

本文介绍了一种利用近红外光谱技术（NIRS）无创连续测量血氧饱和度（St O_2）和血红蛋白绝对体积（Hb vol）的方法。已经设计了一种仪器（PSA-III N）用于该方法的使用，使得可以用三种波长的红外光连续地照射组织表面，并且可以在离照射部位一定距离的点处的组织表面上测量来自组织的散射光。利用朗伯-比尔定律推导出的公式，可以从测量的吸光度无创地确定组织中的St O_2和Hb vol的绝对值。来自PSA-III N的Hb vol值显示组织中Hb vol或血液vol的绝对值。因此，我们应用PSA-III N测量肌肉-血流量。通常，测量组织-血流量是通过静脉闭塞（60 mmHg）体积描记法进行的。因此，我们使用PSA-III N通过静脉闭塞（60 mmHg）测量组织血流量。我们比较了常规方法静脉闭塞（60 mmHg）体积描记法和我们的PSA-III N静脉闭塞（60 mmHg）体积描记法的值。8名男性受试者被用于该实验。每名受试者进行分级的握力练习。在运动过程中，通过两种方法测量肌肉血流量，即，分别采用常规的静脉阻断法（60 mmHg）和PSA-Ⅲ N静脉阻断法（60 mmHg），共获得203个肌血流点。两种方法测得的值之间有显著相关性（r=0.60，p<0.01），说明PSA-Ⅲ N型肌血流量测定仪是一种测量肌肉血流量的仪器，在基础医学和临床医学上有很大的应用价值。