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THE EFFECT OF LH-RH ANALOGUE OR/AND TAMOXIFEN ON BONE IN RATS

THE EFFECT OF LH-RH ANALOGUE OR/AND TAMOXIFEN ON BONE IN RATS
LH-RH类似物或/和他莫昔芬对大鼠骨的影响
批准号:
11671188
负责人:
SUZUKI Yutaka
金额:
$2.3万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1999
资助国家:
日本
项目状态:
已结题
起止时间:
1999 至 2000

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中文摘要
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英文摘要
The effect of LH-RH analogue or/and Tamoxifen on bone in rats were investigated biochemically and histomorphologically. 12-week old female Wistar rats were in the experiment. The animals were divided into five groups. Specifically, there were sham operation group, ovariectomy group, LH-RH analogue (3.6mg) group, LH-RH analogue(3.6mg), given 0.01mg/kg of Tamoxifen group and LH-RH analogue (3.6mg), given 0.1mg/kg of Tamoxifen group. LH-RH agonist was injected hypodermically. Tamoxifen was given orally to the rats. The evaluation of bone disorders was characterrized by reduction in ash content of the femur and histologically by a disappearance of the trabecular bone in femur metaphysis.The metabolic bone disorders developd in injected LH-RH analogue and ovariectomised rats were osteoporosis histomorphologically. The bone mass in rats after stopped LH-RH analogue was increasing. Tamoxifen could not prevent bone volume loss induced LH-RH analogue.
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