Expression of Th2-specific chemokines in bronchial asthma
Expression of Th2-specific chemokines in bronchial asthma
批准号:
12670415
负责人:
ISHII Akira
金额:
$2.05万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2000
资助国家:
日本
项目状态:
已结题
起止时间:
2000 至 2001
中文摘要
我们研究了Th2特异性趋化因子TARC(胸腺和活化调节趋化因子)/CCL17和MDC(巨噬细胞衍生趋化因子)/CCL22在哮喘中的表达。非正常哮喘患者的支气管上皮与TARC呈强烈的免疫反应。MDC仅在哮喘和正常上皮中呈弱阳性,两组间染色强度无明显差异。在IL-4/肿瘤坏死因子-α联合刺激下,支气管上皮细胞释放出ng/ml量的TRAc,但不释放mDC。(Sekiya.T等人的研究成果。与正常人相比,哮喘患者痰和血清中的TARC水平升高。而MDC水平两组间差异无统计学意义。(Seliya.T等人的研究成果。过敏,在新闻中)
英文摘要
We investigated the expression of Th2-specific chemolines, i. e., TARC (thymus and activation regulated chemokine) / CCL 17 and MDC (macrophage-derived chemokine) / CCL22 in bronchial asthma. Bronchial epithelium of asthmatics but not normal exhibited intense immunoreactivity with TARC. MDC immunoreactivty was only weak in both asthmatic and normal epithelium, and no difference of staining intensity was observed in both groups. Bronchial epithelial cell line cells liberated ng/ml quantities of TARC but not MDC in response to combined stimulation with IL-4/TNF-α. (Sekiya. T, et al. J. Immunol.65 : 2205-13, 2000)TARC levels in sputum and serum in asthmatics was increased compared to those in normals. On the other hand, no significant difference was observed in MDC level in both group. (Seliya. T, et al. Allergy, in press)
期刊论文(13)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Sekiya, T., H.Yamada, A.Ishii, K.Hirai., et al.: "Increased levels of a Th2-type CC Chemokines thymus and activation-regulated chemokine (TARC) in induced sputum and serum of asthmatics"Allergy. 57(in press). (2002)
Sekiya, T.、H.Yamada、A.Ishii、K.Hirai. 等人:“哮喘患者诱导痰和血清中 Th2 型 CC 趋化因子胸腺和活化调节趋化因子 (TARC) 水平升高”过敏
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Sekiya, T., H.Yamada, A.Ishii, K.Hirai., et al.: "Increased levels of a Th2-type CC Chemokines thymus and activation-regulated chemokine (TARC) in duced sputum and serum of asthmatics"Allergy. 57(in press). (2002)
Sekiya, T.、H.Yamada、A.Ishii、K.Hirai. 等人:“哮喘患者诱导痰和血清中 Th2 型 CC 趋化因子胸腺和活化调节趋化因子 (TARC) 水平升高”过敏
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Sekiya, T., M.Miyamasu, A.Ishii, K.Hirai., et al.: "Inducible expression of a Th2-type CC Chemokine thymus and activation regulated chemokine (TARC) by human bronchial epithelial Cells"J. Immunol.. 165. 2205-2213 (2000)
Sekiya, T., M.Miyamasu, A.Ishii, K.Hirai., et al.:“人支气管上皮细胞诱导表达 Th2 型 CC 趋化因子胸腺和活化调节趋化因子 (TARC)”J.
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Sakiya, T., M. Miyamasu, A.Ishii, K.Hirai., et al.: "Inducible expression of a Th2-type CC chemokine thymus- and activation-regulated chemokine (TARC) by human bronchial epithelial cells"J. Immunol.. 165. 2205-2213 (2000)
Sakiya, T., M. Miyamasu, A.Ishii, K.Hirai., et al.:“人支气管上皮细胞诱导表达 Th2 型 CC 趋化因子胸腺和激活调节趋化因子 (TARC)”J.
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Ohta, K., N.Yamashita, A.ishii, T.Miyamoto., et al.: "In vivo effects of apoptosis in asthma examined by a murine model"Int. Archi. Allergy Immunol.. 124(1-3). 259-261 (2001)
Ohta,K.,N.Yamashita,A.ishii,T.Miyamoto.,等人:“通过小鼠模型检查哮喘中细胞凋亡的体内影响”Int。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
共 13 条
Research on the McKay correspondence and derived categories
-
批准号:24540041
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2012
-
负责人:ISHII Akira
-
依托单位:
Design and development of supported catalysts due to computational physics and experiments for save and reuse of rare elements for catalyst
-
批准号:23246013
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$31.87万
-
财政年份:2011
-
负责人:ISHII Akira
-
依托单位:
Application of Fourier transformation-linear ion trap mass spectrometers to forensic medicine
-
批准号:23390183
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.32万
-
财政年份:2011
-
负责人:ISHII Akira
-
依托单位:
Neural correlates of mirror system of fatigue.
-
批准号:23700804
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.75万
-
财政年份:2011
-
负责人:ISHII Akira
-
依托单位:
he Health Model for Control of Myopia Progression of the Children
-
批准号:23500805
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.49万
-
财政年份:2011
-
负责人:ISHII Akira
-
依托单位:
Top down approaches to the neural mechanism of fatigue sensation.
-
批准号:22800054
-
项目类别:Grant-in-Aid for Research Activity Start-up
-
资助金额:$1.05万
-
财政年份:2010
-
负责人:ISHII Akira
-
依托单位:
The Late 18th-Century Berlin Manuscript Copies of Contrapuntal Works by the Composers of the 17th and the Early 18th Centuries
-
批准号:22520149
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.66万
-
财政年份:2010
-
负责人:ISHII Akira
-
依托单位:
Research on bio-mimetic machine vision
-
批准号:21560278
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2009
-
负责人:ISHII Akira
-
依托单位:
Moduli spaces and derived categories
-
批准号:21540039
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2009
-
负责人:ISHII Akira
-
依托单位:
Plaque visualization and hemodynamic analysis with magnetic resonance imaging in swine carotid atherosclerosis model
-
批准号:20791009
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.66万
-
财政年份:2008
-
负责人:ISHII Akira
-
依托单位:
Design and Development of semiconductor-supported catalyst for save and recycle of rare elements for catalysis
-
批准号:20560021
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.08万
-
财政年份:2008
-
负责人:ISHII Akira
-
依托单位:
Research on derived categories in algebraic geometry
-
批准号:18540034
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.6万
-
财政年份:2006
-
负责人:ISHII Akira
-
依托单位:
Application of nanoLC/MS/MS to legal medicine
-
批准号:18209025
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$30.7万
-
财政年份:2006
-
负责人:ISHII Akira
-
依托单位:
A Study on Japan-Taiwan Political Relations of the Early Periods of 1960's
-
批准号:16530100
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$0.96万
-
财政年份:2004
-
负责人:ISHII Akira
-
依托单位:
Development of micron-scale crystal growth simulation by using the first-principles calculation
-
批准号:16560023
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2004
-
负责人:ISHII Akira
-
依托单位:
Molecular mechanisms of cytoldne-mediated basophil activation.
-
批准号:15591049
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2003
-
负责人:ISHII Akira
-
依托单位:
Three-dimensional imaging system using a varifocal mirror at video frame rate
-
批准号:14350137
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.58万
-
财政年份:2002
-
负责人:ISHII Akira
-
依托单位:
Application of high-performance liquid chromatography/laser spray mass spectrometry to legal medicine.
-
批准号:14207023
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$27.04万
-
财政年份:2002
-
负责人:ISHII Akira
-
依托单位:
Reevaluation of Sino-Soviet Confrontation
-
批准号:13620083
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.98万
-
财政年份:2001
-
负责人:ISHII Akira
-
依托单位:
Rapid screening of inorganic poisons by column-switching ion chromatography
-
批准号:13557037
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$1.79万
-
财政年份:2001
-
负责人:ISHII Akira
-
依托单位:
国内基金
海外基金
Th1/Th2细胞失衡模式在分泌性中耳炎发病机制中作用的研究
-
批准号:81070777
-
项目类别:面上项目
-
资助金额:32.0万元
-
批准年份:2010
-
负责人:赵守琴
-
依托单位: