Expression of Th2-specific chemokines in bronchial asthma

我们研究了 Th2 特异性趋化因子的表达，即。例如，支气管哮喘中的 TARC（胸腺和活化调节趋化因子）/CCL 17 和 MDC（巨噬细胞衍生趋化因子）/CCL22。哮喘患者而非正常人的支气管上皮与 TARC 表现出强烈的免疫反应性。 MDC免疫反应仅在哮喘和正常上皮中较弱，并且两组中没有观察到染色强度的差异。支气管上皮细胞系细胞响应 IL-4/TNF-α 联合刺激，释放 ng/ml 量的 TARC，但不释放 MDC。 (Sekiya.T，et al.J.Immunol.65：2205-13，2000)哮喘患者的痰和血清中的TARC水平与正常人相比增加。另一方面，两组的MDC水平没有观察到显着差异。 （Seliya. T 等人，过敏症，待出版）

We investigated the expression of Th2-specific chemolines, i. e., TARC (thymus and activation regulated chemokine) / CCL 17 and MDC (macrophage-derived chemokine) / CCL22 in bronchial asthma. Bronchial epithelium of asthmatics but not normal exhibited intense immunoreactivity with TARC. MDC immunoreactivty was only weak in both asthmatic and normal epithelium, and no difference of staining intensity was observed in both groups. Bronchial epithelial cell line cells liberated ng/ml quantities of TARC but not MDC in response to combined stimulation with IL-4/TNF-α. (Sekiya. T, et al. J. Immunol.65 : 2205-13, 2000)TARC levels in sputum and serum in asthmatics was increased compared to those in normals. On the other hand, no significant difference was observed in MDC level in both group. (Seliya. T, et al. Allergy, in press)