Expression of Th2-specific chemokines in bronchial asthma

我们研究了Th2特异性趋化因子TARC(胸腺和活化调节趋化因子)/CCL17和MDC(巨噬细胞衍生趋化因子)/CCL22在哮喘中的表达。非正常哮喘患者的支气管上皮与TARC呈强烈的免疫反应。MDC仅在哮喘和正常上皮中呈弱阳性，两组间染色强度无明显差异。在IL-4/肿瘤坏死因子-α联合刺激下，支气管上皮细胞释放出ng/ml量的TRAc，但不释放mDC。(Sekiya.T等人的研究成果。与正常人相比，哮喘患者痰和血清中的TARC水平升高。而MDC水平两组间差异无统计学意义。(Seliya.T等人的研究成果。过敏，在新闻中)

We investigated the expression of Th2-specific chemolines, i. e., TARC (thymus and activation regulated chemokine) / CCL 17 and MDC (macrophage-derived chemokine) / CCL22 in bronchial asthma. Bronchial epithelium of asthmatics but not normal exhibited intense immunoreactivity with TARC. MDC immunoreactivty was only weak in both asthmatic and normal epithelium, and no difference of staining intensity was observed in both groups. Bronchial epithelial cell line cells liberated ng/ml quantities of TARC but not MDC in response to combined stimulation with IL-4/TNF-α. (Sekiya. T, et al. J. Immunol.65 : 2205-13, 2000)TARC levels in sputum and serum in asthmatics was increased compared to those in normals. On the other hand, no significant difference was observed in MDC level in both group. (Seliya. T, et al. Allergy, in press)