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Plaque visualization and hemodynamic analysis with magnetic resonance imaging in swine carotid atherosclerosis model

Plaque visualization and hemodynamic analysis with magnetic resonance imaging in swine carotid atherosclerosis model
猪颈动脉粥样硬化模型中的斑块可视化和血流动力学分析
批准号:
20791009
负责人:
ISHII Akira
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
The purpose of the present study is to elucidate the role of hemodynamics in atherosclerosis by experimental induction of atherosclerotic plaque in the swine carotid artery. Complex atherosclerotic plaque was successfully induced in the lesion distal to surgical partial ligation. Systolic and diastolic flow velocity were obtained with phase contrast sequence in 3.0 Tesla MRI. Wall shear stress was calculated with the obtained dataset. Shear stress was maintained high in the lesion distal to surgical partial ligation due to unidirectional jet flow. By contrast, in the lesion proximal to ligation, shear stress was found to oscillate during cardiac cycle. Low wall shear stress may contribute to plaque formation in this animal model.
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近赤外線を用いたプラークイメージング
使用近红外光进行斑块成像
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [山田清文, 吉村紳一, 宗光俊博, 宗光俊博, 宗光俊博, 宗光敏博]
通讯作者: 宗光敏博
近赤外線を用いたプラークイメージングの可能性
使用近红外光进行斑块成像的可能性
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [山田清文, 吉村紳一, 宗光俊博, 宗光俊博, 宗光俊博, 宗光敏博, 宗光俊博]
通讯作者: 宗光俊博
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [山田清文, 吉村紳一, 宗光俊博, 宗光俊博, 宗光俊博]
通讯作者: 宗光俊博
近赤外線を用いたプラークイメージングの可能性検討
使用近红外线进行斑块成像的可能性
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [山田清文, 吉村紳一, 宗光俊博, 宗光俊博]
通讯作者: 宗光俊博
7
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