Preventative effects of exercise on the cardiovascular disease, ADL and cognitive function of the elderly with metabolic syndrome

代谢综合征（MetS）是一种腹部肥胖、葡萄糖耐受不良、高血压和血脂异常的聚集性疾病，是老年人健康的核心问题。本研究旨在探讨运动对老年met患者心血管疾病、ADL和认知功能的影响。运动是治疗MetS的重要组成部分，然而，对于老年人来说，继续运动并不总是那么容易。我们首先研究了使用近红外光谱仪（NIRS）对大脑功能的视觉评估可以增加老年人的运动动机。在老年met患者中，NIBS在单词流畅性测试中显示出额叶明显的脑血流激活模式。这一观察的意义目前正在调查中，但对老年人来说足够有用，可以继续为met进行练习。研究老年人met的临床特征。HOMA-IR估计的胰岛素抵抗和met患病率随着年龄的增长而增加。腰围与HOMA-IR之间存在显著的线性关系，在与MetS重叠的IDF和AHA-NHLBI中HOMA-IR高度升高（肥胖MetS），在没有腹部肥胖的AHA-NHLBI-MetS中HOMA-IR也升高（非肥胖MetS）。AHA-NHLBI-MetS伴代谢紊乱聚类是心血管疾病最有效的预测因子。MetS也与老年妇女的ADL下降有关。MetS与心血管疾病和ADL损害相关。运动对心血管疾病、ADL和脑功能的保护作用应通过进一步的老年人前瞻性研究来分析。

Metabolic syndrome (MetS), clustering of abdominal obesity, glucose intolerance, hypertension and dyslipidemia, is a central concern of the health in the elderly. The aim of this study was to investigate the effects of exercise on the cardiovascular disease, ADL, and cognitive function of the elderly with MetS.1. Exercise is an essential component for the treatment of MetS, however, it is not always easy to continue exercise for the elderly. We first investigated that visual evaluation of brain function by using Near InfraRed Spectrometer (NIRS) could increase the motivation for exercise in the elderly. in the elderly with MetS, NIBS demonstrated the distinct pattern of cerebral blood flow activation in the frontal lobe during the test for word fluency. The meaning of this observation is now under the investigation, but was useful enough to have elderly to continue the exercise for MetS.2. Clinical profile of MetS of the elderly was investigated. Insulin resistance estimated by HOMA-IR and prevalence of MetS increased with age. There was a significant linear association between waist circumference and HOMA-IR, which was highly elevated in IDF & AHA-NHLBI overlapping with MetS (obese MetS), and also elevated in AHA-NHLBI-MetS without abdominal obesity (non-obese MetS). AHA-NHLBI-MetS accompanied by clustering of metabolic disorders was the most effective predictor for cardiovascular diseases. MetS was also associated with decreased ADL in the elderly women.MetS was correlated to cardiovascular disease and ADL impairment. Protective effects of exercise on cardiovascular disease, ADL and brain function should be analyzed by further prospective studies in the elderly.