Preventative effects of exercise on the cardiovascular disease, ADL and cognitive function of the elderly with metabolic syndrome

运动对代谢综合征老年人心血管疾病、ADL和认知功能的预防作用

• 批准号: 17500473
• 负责人: SAKURAI Takashi
• 金额: $ 2.41万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17500473/
• 关键词: elderly; metebolic syndrome; excerise; cardioyascular disease; cognitive function; ADL; ADL; メタボリック症候群; 運動療法; 動機付け; 脳機能; 近赤外分光法; 万歩計

Metabolic syndrome (MetS), clustering of abdominal obesity, glucose intolerance, hypertension and dyslipidemia, is a central concern of the health in the elderly. The aim of this study was to investigate the effects of exercise on the cardiovascular disease, ADL, and cognitive function of the elderly with MetS.1. Exercise is an essential component for the treatment of MetS, however, it is not always easy to continue exercise for the elderly. We first investigated that visual evaluation of brain function by using Near InfraRed Spectrometer (NIRS) could increase the motivation for exercise in the elderly. in the elderly with MetS, NIBS demonstrated the distinct pattern of cerebral blood flow activation in the frontal lobe during the test for word fluency. The meaning of this observation is now under the investigation, but was useful enough to have elderly to continue the exercise for MetS.2. Clinical profile of MetS of the elderly was investigated. Insulin resistance estimated by HOMA-IR and prevalence of MetS increased with age. There was a significant linear association between waist circumference and HOMA-IR, which was highly elevated in IDF & AHA-NHLBI overlapping with MetS (obese MetS), and also elevated in AHA-NHLBI-MetS without abdominal obesity (non-obese MetS). AHA-NHLBI-MetS accompanied by clustering of metabolic disorders was the most effective predictor for cardiovascular diseases. MetS was also associated with decreased ADL in the elderly women.MetS was correlated to cardiovascular disease and ADL impairment. Protective effects of exercise on cardiovascular disease, ADL and brain function should be analyzed by further prospective studies in the elderly.

代谢综合征是腹型肥胖、糖耐量异常、高血压和血脂异常的聚集性疾病，是老年人健康的中心问题。本研究旨在探讨运动对代谢综合征1型老年患者心血管疾病、日常生活活动能力和认知功能的影响。运动是治疗代谢综合征的一个重要组成部分，然而，对于老年人来说，继续运动并不总是容易的。本研究首先探讨了近红外光谱仪（NIRS）脑功能视觉评价对老年人运动动机的影响。在老年MetS患者中，NIBS在单词流畅性测试中显示了额叶脑血流激活的独特模式。这一观察结果的意义正在调查中，但足以让老年人继续进行代谢综合征的锻炼。研究老年人代谢综合征的临床特征。胰岛素抵抗估计HOMA-IR和MetS患病率随年龄增加。腰围与HOMA-IR之间存在显著的线性相关性，其在与MetS重叠的IDF和AHA-NHLBI（肥胖MetS）中高度升高，并且在无腹型肥胖的AHA-NHLBI-MetS（非肥胖MetS）中也升高。AHA-NHLBI-MetS合并代谢紊乱聚集是心血管疾病最有效的预测因子。代谢综合征还与老年妇女的日常生活能力下降有关，代谢综合征与心血管疾病和日常生活能力受损有关。运动对老年人心血管疾病、日常生活活动能力和脑功能的保护作用有待于进一步的前瞻性研究。

项目成果

Metabolic syndrome of the elederly

老年人代谢综合征

• 发表时间: 2007
• 作者: Sakurai;T
• 通讯作者: T

生活習慣病ガイドブック

生活方式相关疾病指南

• 发表时间: 2008
• 作者: Yoshino;H;Sakurai;T;et. al.;櫻井 孝
• 通讯作者: 櫻井 孝

Different effects of Monocarboxylates on neuronal survival and beta-amyloid toxicity.

单羧酸盐对神经元存活和 β-淀粉样蛋白毒性的不同影响。

• 发表时间: 2007
• 期刊: Eur J Neurosci 26
• 作者: Wang XN;et. al.
• 通讯作者: et. al.

Screening and recent therapy of the diabetic patients with Alzheimer's disease

糖尿病合并阿尔茨海默病的筛查和近期治疗

• 发表时间: 2007
• 作者: Sakurai T;et. al.
• 通讯作者: et. al.

Neuroprotective Effect of D-Fructose-1,6-Bisphosphate against beta-Amyloid Induced Neurotoxicity in Rat Hippocampal Organotypic Slice Culture : Involvement of PLC and MEK/ERK Signaling Pathways.

D-果糖-1,6-二磷酸对大鼠海马器官切片培养中 β-淀粉样蛋白诱导的神经毒性的神经保护作用：PLC 和 MEK/ERK 信号通路的参与。

• 发表时间: 2005
• 期刊: Kobe Journal of Medical Science 51・5
• 作者: Sakurai;T;et. al.;Kidoguchi K;Morishita A;Oizumi XS;Tamaki M;Akisaki T;Hirano M;Hirano M;Song X
• 通讯作者: Song X