Development of effective conservative combined therapy for malignant tumor using quantitative analysis for vascular structure

利用血管结构定量分析开发有效的恶性肿瘤保守联合疗法

• 批准号: 19592187
• 负责人: SAKURAI Takashi
• 金额: $ 2.83万
• 依托单位: Kanagawa Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19592187/
• 关键词: 放射線療法; 温熱療法; 化学療法; 悪性腫瘍; マウス; KB細胞; ヌードマウス; KB腫瘍; 放射線治療

This study was conducted with two phases of cellular level and in vivo level using experimental animal, for the aim of development of effective conservative combined therapy for malignant tumor. Radiotherapy, chemotherapy and hyperthermia were chosen for the combined therapy, because those were commonly used clinically. The combined therapy that high treatment effect was obtained at a cellular level caused decrease and fragmentation of vascular around a tumor, and it showed high treatment effect for the malignant tumors of mice. Furthermore, it was suggested that we will be able to markedly decrease the prescription dose of each therapy.

本研究分细胞水平和体内水平两个阶段进行实验动物实验，旨在探索有效的恶性肿瘤保守综合治疗方法。放疗、化疗和热疗是临床上常用的综合治疗方法。在细胞水平上取得较高治疗效果的综合疗法，导致肿瘤周围血管减少、碎裂，对小鼠恶性肿瘤显示出较高的治疗效果。此外，有人建议，我们将能够显著减少每种疗法的处方剂量。