Insulin secretion in pancreaticβcells and control of blood glucose level studied by fiber-coupled micro endoscopy
Insulin secretion in pancreaticβcells and control of blood glucose level studied by fiber-coupled micro endoscopy
批准号:
21590231
负责人:
SAKURAI Takashi
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
To elucidate physiological functions of multiple cells or organs exsising deep inside body, we developed a branch-type fiber-coupled confocal microscope(FCM). The spatio-temporal performance of FCM was enough to resolve the fluorescently-labelled granules in the pancreaticβcells. By using FCM, we could measure glucose-dependent fluorescent intensity changes in theβ-granules reflecting secretion of insulin to the blood stream. The FCM may be usefull technique for the understanding of mechanisms or disorders controlling of the blood glucose level.
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DOI:
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发表时间:
2011
期刊:
影响因子:
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作者:
[櫻井孝司, 夏目三男, 秋山喬, 金田雅充, 福司康子, 寺川進]
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发表时间:
2010
期刊:
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[Tamura A, Hayashi H, Imasato M, Yamazaki Y, Hagiwara A, Wada M, Noda T, Watababe M, Suzuki Y. and Tsukita S., 櫻井孝司,須々木礼美,呉鴻,最上秀夫,寺川進]
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发表时间:
2009
期刊:
影响因子:
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[櫻井孝司, 寺川進]
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DOI:
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发表时间:
2009
期刊:
影响因子:
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作者:
[Inagaki-Tachibana, E., Tsukahara, T., Kaji, K., Eguchi, R, Kanazawa, H, Hayashi, H. and Suzuki, Y., 櫻井孝司]
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Microdomain-dependent acceleration mechanisms for amyloidogenic processing of amyloid precursor protein induced by endocytic membrane traffic impairment
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Application of a cell-free protein display technology to the high-throughput functional proteomic screen for regulators of neuron-glia interaction
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Development of a Pulse Detonation Combustor for a Several kW-class Micro Gas Turbine
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A novel microdomain-dependent regulatory mechanism of amyloid precursor protein processing
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资助金额:$12.06万
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Development of effective conservative combined therapy for malignant tumor using quantitative analysis for vascular structure
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A new method for detecting lactate threshold by respiratory rate
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Study on cholesterol-dependent regulatory mechanisms of amyloid precursor protein processing in membrane microdomains
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Preventative effects of exercise on the cardiovascular disease, ADL and cognitive function of the elderly with metabolic syndrome
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Studies on the Process of Magnetic Energy Build-up in Solar Flares by Using an Infrared Detector
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Study on cholesterol-dependent regulatory mechanisms of amyloid precursor protein processing in lipid microdomains
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Magnetic Field Evolution and Solar Flares
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Observations of Solar Eclipse in South America on Nov.3,1994
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Observational Studies of Magnetic Energy Storage and Release in Solar Flares
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海外基金