Mechanisms for molecular cluster formation and specificity in the bio-regulation with glycosphingolipids
Mechanisms for molecular cluster formation and specificity in the bio-regulation with glycosphingolipids
批准号:
19390086
负责人:
FURUKAWA Koichi
金额:
$12.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
スフィンゴ糖脂質による生体調節、とくに分子クラスターの形成プロセスとシグナルの調節機構に関し多くの成果が得られた。糖脂質の欠損では、残存糖脂質構造の代償機能が働く。GM3-only マウスの解析から、細胞膜ミクロドメインの健常性の維持にとって、糖脂質糖鎖の正しい構成が必須であることが、種々の実験から明らかになった。とくに、ラフトの異常が補体系の活性化を惹起して、神経変性の重要な要因となることが示唆された。
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脂質ラフトを介するシグナル制御と糖脂質糖鎮
通过脂筏和糖脂糖基沉积的信号调节
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[古川鋼一, 山内祥生, 浜村和紀, 章青, 大海雄介, 愛新覚羅維, 古川圭子]
通讯作者:
古川圭子
酸性糖脂質GD3によるヒトメラノーマの癌性形質形成におけるSrc family kinasesの役割
Src家族激酶在酸性糖脂GD3诱导的人黑色素瘤癌变中的作用
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[古川圭子, 辻桃子, 浜村和紀, 中島英行, 古川鋼一]
通讯作者:
古川鋼一
DOI:
10.1016/j.bbr.2008.10.024
发表时间:
2009-03-02
期刊:
BEHAVIOURAL BRAIN RESEARCH
影响因子:
2.7
作者:
[Tajima, Orie, Egashira, Nobuaki, Furukawa, Koichi]
通讯作者:
Furukawa, Koichi
ヒトメラノーマにおけるNeus3過剰発現の効果
Neus3 过表达对人黑色素瘤的影响
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[古川圭子, 田島織絵, 神戸真理子, 古川鋼一, 森谷節子, 宮城妙子]
通讯作者:
宮城妙子
a : Roles of integrins in the malignant properties of malignant melanomas enhanced by ganglioside GD3
a:神经节苷脂 GD3 增强整合素在恶性黑色素瘤恶性特性中的作用
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Yuki Ohkawa, Sayaka Miyazaki, Kazunori Hamamura, Maiko Miyata, Koichi FurukawOrie Tajima, Keiko Furukawa]
通讯作者:
Keiko Furukawa
共 47 条
Regulatory mechanisms for microenvironment and metastasis of cancers with glycosphigolipids via extracellular vesicles
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批准号:17K19616
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项目类别:Grant-in-Aid for Challenging Research (Exploratory)
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资助金额:$4.16万
-
财政年份:2017
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负责人:FURUKAWA Koichi
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依托单位:
Integrative understanding of linkage between molecular structures and functions of glycosphingolipids in signal regulation
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批准号:15H04696
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.15万
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财政年份:2015
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负责人:FURUKAWA Koichi
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依托单位:
Mechanisms for innate immune check-point generated by siglecs and sialic acid-containing carbohydrates
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批准号:15K15080
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2015
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负责人:FURUKAWA Koichi
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依托单位:
Supporting Skill Development by Rule Abduction and Analogy
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批准号:24500183
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2012
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负责人:FURUKAWA Koichi
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依托单位:
Molecular mechanisms for signals generated by the interaction between glycosphingolipids on the cell membrane and their ligands
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批准号:24390078
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.98万
-
财政年份:2012
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负责人:FURUKAWA Koichi
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依托单位:
Bioprotection mechanisms by specific binding of globo-series glycosphingolipids to LPS receptors
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批准号:23659171
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2011
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负责人:FURUKAWA Koichi
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依托单位:
Measuring Risk under Uncertainty and Competition, Game Theotetical Approach to Real Option Valuation
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批准号:17510128
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2005
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负责人:FURUKAWA Koichi
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依托单位:
Real Option Analysis with the Strategic Thinking -Risk Management under Competition-
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批准号:14580482
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:2002
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负责人:FURUKAWA Koichi
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依托单位:
Function regulation of proteins and molecular complexes with glycosylation.
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批准号:14082101
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$72.9万
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财政年份:2002
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负责人:FURUKAWA Koichi
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依托单位:
Microdomain abnormalities due to aberrant glycolipids
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批准号:14082102
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$147.26万
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财政年份:2002
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负责人:FURUKAWA Koichi
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依托单位:
Analysis of in vivo function of glycosphingolipids with glycosylation mutant mice
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批准号:13470021
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.28万
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财政年份:2001
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负责人:FURUKAWA Koichi
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依托单位:
The regulation of growth and differentiation signales of nerve cells bar sphingoglycolipids.
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批准号:10470029
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.0万
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财政年份:1998
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负责人:FURUKAWA Koichi
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依托单位:
Variable Aspects of Promotion to Starting Up Ventures and Problems of Management of Ventures
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批准号:09430022
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.86万
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财政年份:1997
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负责人:FURUKAWA Koichi
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依托单位:
Research on the Cognitive Process of second language vocabulary learning and its application to machine translation
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批准号:07680411
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.6万
-
财政年份:1995
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负责人:FURUKAWA Koichi
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依托单位:
Regulation of expression and function of GM2/GD2 synthase gene in the development and repairment of nerve tissue.
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批准号:06670232
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1994
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负责人:FURUKAWA Koichi
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依托单位:
Research on Discovery and Creative Process Modelling in Logic
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批准号:05452360
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项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$4.16万
-
财政年份:1993
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负责人:FURUKAWA Koichi
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依托单位:
Analysis of requlatory mechanism for cell proliferation by modification of gangliosides
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批准号:05807018
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.15万
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财政年份:1993
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负责人:FURUKAWA Koichi
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依托单位:
Mechanism and therapeutic application of the gangliosides specifically expressed in ATL and HTLV-I infected cells.
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批准号:03671191
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1991
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负责人:FURUKAWA Koichi
-
依托单位:
海外基金