Optical and Nuclear Imaging of Tumor-related genes

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We have developed the simple preparation of Tc-99m-labeled or fluorophore-labeled nanoparticle which was reactive to mRNA in the tumor specifically. Nanoparticle consisted of Antisense-oligonucleotides and streptavidin or biotin. We have also developed second-generation nanoparticles which consisted of Antisense-oligonucleotides and streptavidin or biotin and monoclonal antibody which recognized the tumor specific receptor. HER2, which over expressed in the breast tumor implanted in the thigh of mouse, was viewed very clearly when Tc-99m-labeled nanoparticle was injected intravenously.