Roll of interleukin-32 in inflammatory bone resorption caused by periodontopathic bacterium

白细胞介素32在牙周病细菌引起的炎性骨吸收中的作用

• 批准号: 19592123
• 负责人: TSUJISAWA Toshiyuki
• 金额: $ 2.83万
• 依托单位: Kyushu Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19592123/
• 关键词: 炎症; サイトカイン; インターロイキン; リポ多糖; 自然免疫; 歯周病原性細菌; 骨代謝; 歯周病原細菌

We examined whether lipopolysaccaride (LPS) derived from Aggregatibacter actinomycetemcomitans, one of periodontopathic bacteria, induce expression of interlukin-32. We also analyzed the induction mechanism of IL-32 in human monocyte. Scince an inhibitor of NF-kB, one of downstream signaling of Toll-like receptor 4, inhibits the expression of IL-32, it was suggested that NF-kB activation was involved in the induction of IL-32 by LPS.

我们研究了牙周病致病菌之一伴放线菌凝聚菌的脂多糖（LPS）是否诱导白细胞介素-32的表达。并对IL-32在人单核细胞中的诱导机制进行了分析。由于Toll样受体4下游信号通路之一的NF-κ B的抑制剂可抑制IL-32的表达，提示NF-κ B的活化参与了LPS诱导IL-32的产生。

项目成果

Effects of lipopolysaccharide on newly established rat dental pulp-derived cell line with odontoblastic properties

• DOI: 10.1016/j.joen.2007.05.015
• 发表时间: 2007-10-01
• 期刊: JOURNAL OF ENDODONTICS
• 影响因子: 4.2
• 作者: Nomiyama, Kimiko;Kitamura, Chiaki;Nishihara, Tatsuji
• 通讯作者: Nishihara, Tatsuji