Role of T cells in the innate immune response during sepsis

在健康情况下，T细胞存在于腹膜中。Rag2Ko小鼠（T和B细胞缺陷）在败血症期间的死亡率增加，在过继性转移T细胞后恢复，但B细胞没有恢复。在T细胞中过表达SOCS5的小鼠（SOCS5- ctg）表现出腹膜Th1反应增加，而SOCS3-cTg小鼠在脓毒性腹膜炎期间表现出全身炎症反应减少，导致脓毒症期间存活率增加。因此，T细胞似乎在先天免疫中很重要，先天免疫可以由T细胞中的SOCS3/5控制。我们还阐明了T细胞在不同类型炎症模型中的关键作用，如T细胞依赖性肝炎和关节炎。

T cells exist in the peritoneum under healthy conditions. Rag2Ko mice (T and B cell deficient) showed increased mortality rate during sepsis, which was recovered after adoptive transfer of T cells, but not B cells. Mice with overexpression of SOCS5 in T cells (SOCS5-cTg) demonstrated increased Th1 response in the peritoneum whereas SOCS3-cTg mice exhibited decreased systemic inflammatory response during septic peritonitis, leading to the increased survival rate during sepsis. Thus, T cells appear to be important in innate immunity, which can be controlled by SOCS3/5 in T cells. We also elucidated the crucial roles of T cells in different types of inflammation models, such as T cell-dependent hepatitis and arthritis.