Importance of host response for the development of chronic gastritis induced by infection with Helicobacter pylori.

幽门螺杆菌是一种革兰氏阴性的细胞外细菌，与慢性胃炎和胃癌的发生有关。我们现在知道，使用抗生素和质子泵抑制剂的标准治疗幽门螺杆菌对预防胃病是有益的。然而，我们面对许多病例对治疗产生耐药性，并遭受再感染。在这里，我们研究了宿主对幽门螺杆菌的反应是否以及如何参与这些疾病的发展。在H. pylori感染的小鼠此外，IL-33是一种通过诱导IL-13/IL-5和嗜酸性粒细胞趋化因子而触发嗜酸性粒细胞活化和募集的强效细胞因子，其是慢性胃炎发展所必需的。事实上，Il 33 r ^<-/->小鼠对由H.幽门螺杆菌和受损的清除细菌。这些结果表明IL-33是预防慢性胃炎和胃癌的有效靶点。

Helicobacter pylori is a Gram-negative, extracellular bacterium and is involved in the development of chronic gastritis and gastric cancer. We now know that the standard therapy against H.pylori using antibiotics and proton pomp inhibitor are beneficial for prevention of the gastric diseases. However, we have faced upon many cases that are resistant to the therapy and suffer from the re-infection. Here, we investigated whether and how host responses against H.pylori are involved in the development of those diseases. And we found that many eosinophils are infiltrated in the inflammatory sites of chronic gastritis in H. pylori-infected mice. Furthermore, IL-33, a potent cytokine triggering activation and recruitment of eosinophils via induction of IL-13/IL-5 and chemokines for eosinophils, is essentially required for the development of chronic gastritis. Indeed, Il33r^<-/-> mice are resistant to chronic gastritis induced by infection with H. pylori and are impaired in the clearance of the bacterium. These results indicated IL-33 as a potent target for protection against the chronic gastritis and plausibly gastric cancer.