New immune regulatory mechanism by paired receptors

在这项研究中，我们试图阐明配对受体的宿主和病原体配体。通过这一分析，我们分析了抑制性受体如何调节对自身的免疫反应，以及病原体如何通过抑制性受体逃避免疫反应。此外，我们分析了激活受体如何参与宿主对病原体的抗性。我们对PILR的功能进行了深入的分析。我们发现PILR与单纯疱疹病毒的糖蛋白B结合，并参与单纯疱疹病毒进入细胞。此外，我们还发现CD 99和糖蛋白B上的特异性O-聚糖对于PILR的结合是必需的。此外，我们还发现了一种新的神经组织特异性表达的分子PANP，它是PILR的一种新的配体，提示PANP可能参与神经组织的免疫调节。这些结果表明，配对受体在免疫调节中起重要作用。

In this study, we tried to elucidate host and pathogen ligands for paired receptors. By this analysis, we analyzed how immune response to self is regulated via inhibitory receptors and how pathogens evade immune response via inhibitory receptors. In addition, we analyzed how activating receptors is involved in host resistance to pathogens. We extensively analyzed function of PILR, one of paired receptors. We found that PILR associates with glycoprotein B of herpes simplex virus and is involved in entry of herpes simplex virus into cells. Furthermore, we found that specific O-glycans on CD99 and glycoprotein B are essential to associate with PILR. In addition, we identified PANP, a new molecules that is specifically expressed in nerve tissue, as a new ligand for PILR and suggested that PANP might be involved in the immune regulation in nerve tissues. These results suggested that paired receptors play an important role in immune regulation.