New immune regulatory mechanism by paired receptors

在这项研究中，我们试图阐明成对受体的宿主和病原体配体。通过这种分析，我们分析了对自身的免疫反应是如何通过抑制性受体调节的，以及病原体是如何通过抑制性受体逃避免疫反应的。此外，我们还分析了激活受体如何参与宿主对病原菌的抗性。我们广泛地分析了PILR的功能，PILR是配对受体之一。我们发现PILR与单纯疱疹病毒糖蛋白B结合，参与了单纯疱疹病毒进入细胞的过程。此外，我们还发现CD99和糖蛋白B上的特异性O-糖链是与PILR相关的关键。此外，我们还发现PANP是一种在神经组织中特异表达的新分子，是PILR的新配体，提示PANP可能参与了神经组织的免疫调节。这些结果表明，成对受体在免疫调节中起着重要作用。

In this study, we tried to elucidate host and pathogen ligands for paired receptors. By this analysis, we analyzed how immune response to self is regulated via inhibitory receptors and how pathogens evade immune response via inhibitory receptors. In addition, we analyzed how activating receptors is involved in host resistance to pathogens. We extensively analyzed function of PILR, one of paired receptors. We found that PILR associates with glycoprotein B of herpes simplex virus and is involved in entry of herpes simplex virus into cells. Furthermore, we found that specific O-glycans on CD99 and glycoprotein B are essential to associate with PILR. In addition, we identified PANP, a new molecules that is specifically expressed in nerve tissue, as a new ligand for PILR and suggested that PANP might be involved in the immune regulation in nerve tissues. These results suggested that paired receptors play an important role in immune regulation.