New immune regulatory mechanism by paired receptors

配对受体的新免疫调节机制

• 批准号: 20390143
• 负责人: ARASE Hisashi
• 金额: $ 12.56万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390143/
• 关键词: NK細胞; 自然免疫; 免疫制御; 炎症; 獲得免疫; 好中球; T細; PILR; DCIR; ヘルペスウィルス; 宿主病原体相互作用; ペア型レセプター; 抑制化レセプター

In this study, we tried to elucidate host and pathogen ligands for paired receptors. By this analysis, we analyzed how immune response to self is regulated via inhibitory receptors and how pathogens evade immune response via inhibitory receptors. In addition, we analyzed how activating receptors is involved in host resistance to pathogens. We extensively analyzed function of PILR, one of paired receptors. We found that PILR associates with glycoprotein B of herpes simplex virus and is involved in entry of herpes simplex virus into cells. Furthermore, we found that specific O-glycans on CD99 and glycoprotein B are essential to associate with PILR. In addition, we identified PANP, a new molecules that is specifically expressed in nerve tissue, as a new ligand for PILR and suggested that PANP might be involved in the immune regulation in nerve tissues. These results suggested that paired receptors play an important role in immune regulation.

在这项研究中，我们试图阐明配对受体的宿主和病原体配体。通过此分析，我们分析了如何通过抑制性受体调节对自我的免疫反应，以及病原体如何通过抑制受体逃避免疫反应。此外，我们分析了激活受体如何参与宿主对病原体的抗性。我们广泛分析了配对受体之一PILR的功能。我们发现，PILR与单纯疱疹病毒的糖蛋白B相关，并参与了单纯疱疹病毒进入细胞。此外，我们发现CD99和糖蛋白B上的特定O-聚糖对于与PILR相关性至关重要。此外，我们确定了在神经组织中特异性表达的一种新分子，是PILR的新配体，并建议泛PANP参与神经组织中的免疫调节。这些结果表明，配对受体在免疫调节中起重要作用。

项目成果

Immune Evasion of Varicella-Zoster Virus (VZV) via Siglec-7

通过 Siglec-7 免疫逃避水痘带状疱疹病毒 (VZV)

• 发表时间: 2009
• 作者: Tadahiro Suenaga;Fuminori Arisawa;Hisashi Arase
• 通讯作者: Hisashi Arase

Myelin-Associated Glycoprotein Associates with gB and is Involved in Membrane Fusion during Neurotropic Herpesvirus Infection

髓磷脂相关糖蛋白与 gB 结合并参与嗜神经性疱疹病毒感染期间的膜融合

• 发表时间: 2010
• 作者: Tadahiro Suenaga;Fuminori Arisawa;Takeshi Satoh;Pranee Somboonthum;Yasuko Mori;Yasushi Kawaguchi;Hisashi Arase.
• 通讯作者: Hisashi Arase.

抑制化レセプターPIERを介した単純ヘルペスウィルス感染機構

单纯疱疹病毒通过抑制性受体PIER感染的机制

• 发表时间: 2008
• 作者: Kouro;T.;Takatsu;K.;荒瀬尚
• 通讯作者: 荒瀬尚

Binding and uptake of H-ferritin are mediated by human transferrin receptor-1

• DOI: 10.1073/pnas.0913192107
• 发表时间: 2010-02-23
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Li, Li;Fang, Celia J.;Seaman, William E.
• 通讯作者: Seaman, William E.

ペア型レセプターを介したヘルペスウイルス感染制御機構

配对受体介导的疱疹病毒感染控制机制

• 发表时间: 2010
• 作者: Hikosaka Y;Nitta T;Ohigashi I;Yano K;Ishimaru N;Hayashi Y;Matsumoto M;Matsuo K;Penninger JM;Takayanagi H;Yokota Y;Yamada H;Yoshikai Y;Inoue J;Akiyama T;Takahama Y.;荒瀬尚
• 通讯作者: 荒瀬尚