Driving force of paracellular transport and its control by intracellular signals.

细胞旁运输的驱动力及其细胞内信号的控制。

• 批准号: 20590225
• 负责人: MURAKAMI Masataka
• 金额: $ 3万
• 依托单位: National Institute for Physiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590225/
• 关键词: 唾液腺; タイト結合; 傍細胞輸送; 血管灌流; 水輸送; 細胞内信号; 蛍光物質分泌; 駆動力

The isolated and vascularly perfused mandibular gland of rat was used to assess driving force of paracellular water/solute transport and its control by intracellular signals. The intracellular cAMP-increasing stimulant opens tight junction and induces small paracellular fluid secretion by increasing perfusion pressure. The intracellular Ca-increasing stimulant also opens the tight junction and induced a massive paracellular water/solute transport by perfusion pressure and additional unknown driving force.

采用离体大鼠下颌腺血管灌流模型，研究了细胞内信号对水/溶质转运的驱动力及其调控作用。细胞内cAMP增加刺激剂通过增加灌注压打开紧密连接并诱导小的细胞旁液体分泌。细胞内钙增加刺激剂也打开紧密连接，并诱导大量的细胞旁水/溶质运输灌注压和额外的未知驱动力。

项目成果

Magnetic resonance imaging of the temporomandibular joint in the rat compared with low-powered light microscopy.

大鼠颞下颌关节的磁共振成像与低倍光学显微镜的比较。

• DOI: 10.1016/j.archoralbio.2011.03.024
• 发表时间: 2011
• 期刊: Arch. Oral Biol.
• 作者: 岸田朋子;泉川由布;小高健三;新井繁幸，冨丘 聡，兒島憲一郎，種本雅之，内田俊也;Tochihara K
• 通讯作者: Tochihara K

Effect of chinese herbs on salivary fluid secretion by the isolated and perfused rat submandibular gland

中药对离体灌注大鼠颌下腺唾液分泌的影响

• 发表时间: 2009
• 期刊: World Journal of Gastroentenology 15
• 作者: Katakura M;Hashimoto M;H.M.Shahdat;S.Gamoh;T Okui;Kentaro Matsuzaki;Shido O;Murakami M
• 通讯作者: Murakami M

血管灌流ラット顎下腺の傍細胞輸送に対する静水圧の影響

静水压对血管灌注大鼠颌下腺细胞旁路运输的影响

• 发表时间: 2010
• 作者: Migita K.;Honda K.;Yamada J.;et al;村上政隆
• 通讯作者: 村上政隆

Hydorostatic pressure contributes the driving force partially for the paracellular fluid secretion by isolated perfused submandibular salivary gland.

静水压为分离的下颌下唾液腺灌注的细胞旁液分泌提供部分驱动力。

• 发表时间: 2010
• 作者: Mitsushima D;Takase K;Funabashi T;Kimura F.;Murakami M
• 通讯作者: Murakami M

Morphological evidence of paracellular transport in perfused rat submandibular gland

灌注大鼠颌下腺中细胞旁运输的形态学证据

• 发表时间: 2009
• 作者: Hashimoto S;Murakami M
• 通讯作者: Murakami M