Epidemiological study on the association between the autonomic function and glucose intolerance

本研究旨在探讨日本人的自主神经功能与葡萄糖耐量之间的关系。研究了1032名未接受治疗的糖尿病患者。根据5 min内的R-R间期检测代表植物神经功能的指标，并进行75 g葡萄糖耐量试验。所有正常R-R间期（SDDN）和心率变异性（HRV）指数的标准差高水平与IGT或糖尿病的比值比降低显著相关。在调整BMI、舒张压、使用抗高血压药物、体力活动、吸烟和饮酒后，这些显著相关性仍然存在。我们的数据表明，自主神经系统可能会影响一般日本人群的葡萄糖耐受不良和糖尿病。

Aim of study was to examine the association between the autonomic function and glucose tolerance in Japanese. 1032 individuals who were free of treated diabetes were studied. Indices representing the autonomic function were examined based on the R-R intervals during 5 min, and 75g oral glucose tolerance test was done for them. High levels of the standard deviation of all normal R-R intervals (SDDN) and heart rate variability (HRV) index were significantly associated with decreased odds ratios for IGT or diabetes. The significant associations were remained after adjustment of BMI, diastolic blood pressure, a use of antihypertensive agents, physical activity, smoking, and alcohol drinking. Our data suggest that autonomic nervous system may influence the glucose intolerance and diabetes among the general Japanese population.