Involvement of transcription factor MRTF in the oncogenic process.

在这项研究中，我证明了转录因子MRTF（心肌蛋白相关转录因子）通过转录调节肌动蛋白细胞骨架基因来调节v-ras和v-src转化体中细胞侵袭和转移的活性。此外，myocardin调节作为细胞周期进程抑制剂的p21基因的表达，并且在平滑肌肉瘤细胞中myocardin表达水平降低，导致细胞周期进程增强。组成型活性MRTF或myocardin的外源性表达抑制转化体和平滑肌肉瘤细胞的致癌特性。

In this study, I demonstrated that transcription factor MRTF (myocardin-related transcription factor) regulates the activity of cell invasion and metastasis in the v-ras and v-src transformants via transcriptional regulation of the actin cytoskeletal genes. Further, myocardin regulates the expression of p21 gene, which is inhibitor of cell cycle progression, and in leiomyosarcoma cells myocardin expression level is decreased, leading to enhancement of cell cycle progression. Exogenous expression of constitutively active MRTF or myocardin inhibits the oncogenic properties of the transformants and leimyosarcoma cells.