The role of DCIR in the immune regulation

本研究发现，DCIR不仅参与关节炎的发展，还参与其他免疫相关疾病的发展，如其他实验性自身免疫性和过敏性疾病。此外，我们鉴定了DCIR的内源性碳水化合物配体，并表明该配体可以向DCIR输入抑制信号。并对在关节炎病理分析中发现的DCIR在骨代谢中的作用进行了检测，发现DCIR不仅在dc中起作用，在破骨细胞和成骨细胞中也起作用。这些发现应该支持开发免疫相关疾病的新疗法。

In this study, it was revealed that DCIR functions not only the development of arthritis, but also the development of other immune-related diseases such as other experimental autoimmune and allergic diseases. Moreover, we identified an endogenous carbohydrate ligand for DCIR, and showed that the ligand can input inhibitory signal to DCIR. And the role of DCIR in the bone metabolism, which was discovered during the pathological analysis of arthritis, is also examined and found that DCIR functions not only in DCs, but also in osteoclasts and osteoblasts. These findings should support the development of new therapeutics for immune-related diseases.