Normal tension glaucoma model: Characterization of retinal neuron specific BDNF and cfos knockout
Normal tension glaucoma model: Characterization of retinal neuron specific BDNF and cfos knockout
批准号:
20791257
负责人:
KOBAYASHI Takeshi
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
Retinal neuron specific (Brain-derived neurotrophic factor) BDNF and cfos knockout were studied to characterize the phenotypical change in retinal ganglion cells (RGC). In BDNF knockout, RGC gradually decrease from peripheral potion of retina by aging. Reduction ratio of RGC in cfos knockout was higher than that of RGC in BDNF knockout. Neural retina of cfos knockout did not express mBdnf. It suggest cfos is upstream of BDNF and other neuroprotective factor in the mouse retina. For preventing normal tension glaucoma, neuroprotective transcription factor should be analyzed.
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DOI:
--
发表时间:
2009
期刊:
Molecular Vision. 15
影响因子:
--
作者:
[Kobayashi T, Yoshioka R, Shiraishi A, Ohashi Y]
通讯作者:
Ohashi Y
コラーゲンゲルを用いた培養ヒト角膜上皮シートの作製とその評価
胶原凝胶培养人角膜上皮片的制备及其评价
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[小林剛, 白石敦, 原祐子, 門田裕子, 楊旅軍, 白方裕司, 橋本公二, 大橋裕一]
通讯作者:
大橋裕一
DOI:
10.1264/jsme2.23.149
发表时间:
2008-01-01
期刊:
MICROBES AND ENVIRONMENTS
影响因子:
2.2
作者:
[Suzuki, Satoru, Kobayashi, Takeshi, Tana, Touch Seang]
通讯作者:
Tana, Touch Seang
凍結保存細胞によるヒト培養角膜上皮シートの作製
冻存细胞制备人培养角膜上皮片
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[小林剛, 白石敦, 楊旅軍, 白方裕司, 橋本公二, 大橋裕一]
通讯作者:
大橋裕一
コラーゲンゲルを用いた角膜上皮培養系における上皮-実質間相互作用の検討
使用胶原凝胶检查角膜上皮培养系统中的上皮-基质相互作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[小林剛, 白石敦, 楊旅軍, 白方裕司, 橋本公二, 大橋裕一]
通讯作者:
大橋裕一
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