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a novel therapy of functioning pituitary adenomas using attenuated secretory machinery focusing porosome

a novel therapy of functioning pituitary adenomas using attenuated secretory machinery focusing porosome
使用聚焦多孔体的减弱分泌机制治疗功能性垂体腺瘤的新疗法
批准号:
20591723
负责人:
MATSUNO Akira
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Porosome was identified in an experimental rat pituitary cell expressing fluorophore-combined growth hormone. Both VAMP and fodrin were essential for the secretion of growth hormone. The suppression of these molecules induced the attenuated secretion of growth hormone. These results suggest that the suppression of VAMP and fodrin and the suppressed function of porosome will be a novel therapeutic target of growth hormone-producing pituitary adenomas.
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会议论文
下垂体細胞における下垂体ホルモンmRNAと蛋白の細胞内発現と細胞内動態、分泌機構の可視化
垂体细胞中垂体激素 mRNA 和蛋白的细胞内表达、细胞内动态和分泌机制的可视化
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Matsuno A, Yamada S, Yamada SM, Nakaguchi H, Hoya K, Murakami M, 松野彰]
通讯作者: 松野彰
Microsurgery and neuroendoscopic surgery of pituitary tumors with medical and pathological studies
垂体瘤的显微外科和神经内窥镜手术的医学和病理学研究
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Matsuno A, Yamada S, Yamada SM, Nakaguchi H, Hoya K, Murakami M, 松野彰, Matsuno A, Matsuno A]
通讯作者: Matsuno A
Intravenous rituximab combined with temozolomide as a second line therapy for CD20 positive primary central nervous system malignant lymphoma.
静脉注射利妥昔单抗联合替莫唑胺作为 CD20 阳性原发性中枢神经系统恶性淋巴瘤的二线治疗。
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Matsuno A, Murakami M, Nakaguchi H, Sasaki M, Uno T, Ide F, Tanaka H, Fujimaki T]
通讯作者: Fujimaki T
DOI: 10.3349/ymj.2011.52.6.1031
发表时间: 2011-11-01
期刊: YONSEI MEDICAL JOURNAL
影响因子: 2.4
作者: [Murakami, Mineko, Fujimaki, Takamitsu, Matsuno, Akira]
通讯作者: Matsuno, Akira
42
    Study on role of motor proteins in intracellular transport of pituitary hormone
    • 批准号:
      18591608
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.4万
    • 财政年份:
      2006
    • 负责人:
      MATSUNO Akira
    • 依托单位:
    Study on the molecular mechanism of the secretion of pituitary hormofie
    • 批准号:
      14571334
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.18万
    • 财政年份:
      2002
    • 负责人:
      MATSUNO Akira
    • 依托单位:
    Studies on a novel gene therapy of glioma using antisense oligonucletide for microtubule-associated protein mRNA
    • 批准号:
      09671450
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.05万
    • 财政年份:
      1997
    • 负责人:
      MATSUNO Akira
    • 依托单位:
    Study on the endocrine function and cytogenesis of pituitary adenomas
    • 批准号:
      03454344
    • 项目类别:
      Grant-in-Aid for General Scientific Research (B)
    • 资助金额:
      $3.97万
    • 财政年份:
      1991
    • 负责人:
      MATSUNO Akira
    • 依托单位:
    海外基金