Analysis of the elevated expression of cartducin gene in osteosarcoma and the mechanisms of tumor development

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Cartducin is expressed in human osteosarcomas. The mRNA level of Cartducin was increased in murine osteosarcoma cell lines compared with its level in normal murine osteoblastic cells. The protein level of Cartducin was also increased in these osteosarcoma cell lines. Stimulation of these osteosarcoma cells by Cartducin promoted tumor cell growth but not migration in vitro. Further, Cartducin stimulation led to the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) in these osteosarcoma cell lines. Our results suggest that Cartducin expression may play a role in osteosarcoma tumor growth associated with activation of the ERK1/2 signaling pathway.