Analysis of the elevated expression of cartducin gene in osteosarcoma and the mechanisms of tumor development

骨肉瘤中cartducin基因表达升高及肿瘤发生机制分析

• 批准号: 20592197
• 负责人: MAEDA Takashi
• 金额: $ 3万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592197/
• 关键词: カートデューシン; 骨肉腫細胞; 増殖; 遊走; 浸潤; ERK1; 2; ERK1/2; p38-MAPK; TGF-beta

Cartducin is expressed in human osteosarcomas. The mRNA level of Cartducin was increased in murine osteosarcoma cell lines compared with its level in normal murine osteoblastic cells. The protein level of Cartducin was also increased in these osteosarcoma cell lines. Stimulation of these osteosarcoma cells by Cartducin promoted tumor cell growth but not migration in vitro. Further, Cartducin stimulation led to the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) in these osteosarcoma cell lines. Our results suggest that Cartducin expression may play a role in osteosarcoma tumor growth associated with activation of the ERK1/2 signaling pathway.

Cartducin在人骨肉瘤中表达。Cartducin在小鼠骨肉瘤细胞系中的mRNA水平与其在正常小鼠成骨细胞中的水平相比有所增加。Cartducin的蛋白水平也在这些骨肉瘤细胞系中增加。这些骨肉瘤细胞的Cartducin刺激促进肿瘤细胞的生长，但在体外迁移。此外，Cartducin刺激导致这些骨肉瘤细胞系中细胞外信号调节激酶1/2（ERK 1/2）的激活。我们的结果表明Cartducin表达可能在与ERK 1/2信号通路激活相关的骨肉瘤肿瘤生长中发挥作用。

项目成果

骨肉腫細胞におけるC1qTNFファミリー分泌蛋白CTRP3/cartducinの発現増強と増殖促進作用

C1qTNF家族分泌蛋白CTRP3/cartducin在骨肉瘤细胞中的表达增强及促生长作用

• 发表时间: 2009
• 作者: 前田隆史;脇坂聡
• 通讯作者: 脇坂聡

Metallic artifacts caused by dental metal prostheses on caused by dental metal prostheses on PET images : a PET/CT phantom study using different PET/CT scanners.

PET 图像上由牙科金属假体引起的金属伪影：使用不同 PET/CT 扫描仪的 PET/CT 模型研究。

• 发表时间: 2009
• 期刊: Ann.Nucl.Med. 23
• 作者: Shimamoto H;Kakimoto N;Fujino K;Hamada S;Shimosegawa E;Murakami S;Furukawa S;Hatakezawa J.
• 通讯作者: Hatakezawa J.

Diagnostic imaging findings for mandibular metastasis from gastric adenocarcinoma.

胃腺癌下颌转移的影像诊断结果。

• 发表时间: 2009
• 期刊: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 107(6)
• 作者: Uchiyama Y;Murakami S;Kakimoto N;Nakatani A;Kishino M;Hamab Y;Furukawa S.
• 通讯作者: Furukawa S.

CTRP3/cartducin is induced by transforming growth factor-beta1 and promotes vascular smooth muscle cell proliferation.

CTRP3/cartducin 由转化生长因子-β1 诱导，促进血管平滑肌细胞增殖。

• 发表时间: 2010
• 期刊: Cell Biol.Int. 34
• 作者: Maeda T;Wakisaka S.
• 通讯作者: Wakisaka S.

マウス下顎頭軟骨の発生過程におけるCartducinの発現と機能解析

Cartducin在小鼠下颌髁软骨发育过程中的表达及功能分析

• 发表时间: 2009
• 作者: Tamaki Yokohama-Tamaki;Shibata S.,Wakisaka S.,Harada H;Tamaki Yokohama-Tamaki;田巻玉器,前田隆史,柴田俊一
• 通讯作者: 田巻玉器,前田隆史,柴田俊一