Foam cell formation and atherosclerosis induced by periodontal pathogens.

牙周病原体诱导的泡沫细胞形成和动脉粥样硬化。

• 批准号: 20592398
• 负责人: OKAHASHI Nobuo
• 金额: $ 2.91万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592398/
• 关键词: 口腔レンサ球菌; 泡沫細胞; マクロファージ; 動脈硬化; 歯周病; S.sanguinis; S. sanguinis; 口腔細菌; A. actinomycetemcomitans

Recent investigations suggest that one of the risk factor of atherosclerosis is periodontitis. In the study, we found that oral S. sanguinis stimulates foam cell formation from human macrophage cell line THP-1. Both viable and heat-killed S. sanguinis was capable of inducing foam cell formation. However, large amount of viable cells induced cell death of infected macrophages. The cell death was found to be related to the production of reactive oxygen species. These results suggest possible involvement of oral streptococci in the pathogenesis of atherosclerosis as well as in that of infectious endocarditis.

最近的研究表明，牙周炎是动脉粥样硬化的危险因素之一。在这项研究中，我们发现口服血链球菌可以刺激人巨噬细胞系THP-1的泡沫细胞形成。活的和热灭活的血链球菌都能诱导泡沫细胞的形成。然而，大量活细胞导致感染的巨噬细胞死亡。细胞死亡与活性氧的产生有关。这些结果提示口腔链球菌可能参与动脉粥样硬化和感染性心内膜炎的发病机制。

项目成果

Effects of recombinase A deficiency on biofilm formation by Streptococcus mutans

• DOI: 10.1111/j.1399-302x.2008.00480.x
• 发表时间: 2009-04-01
• 期刊: ORAL MICROBIOLOGY AND IMMUNOLOGY
• 作者: Inagaki, S.;Matsumoto-Nakano, M.;Ooshima, T.
• 通讯作者: Ooshima, T.

Presence of serotype k strains of Streptococcus mutans is a poteitial risk factor for cerebral hemorrhage

变形链球菌 k 血清型菌株的存在是脑出血的潜在危险因素

• 发表时间: 2009
• 作者: Nakano K;Taniguchi N;他
• 通讯作者: 他

Protein antigen in serotype k Streptococcus mutans clinical isolates

• DOI: 10.1177/154405910808701001
• 发表时间: 2008-10-01
• 期刊: JOURNAL OF DENTAL RESEARCH
• 影响因子: 7.6
• 作者: Nakano, K.;Nomura, R.;Ooshima, T.
• 通讯作者: Ooshima, T.

Contribution of cell surface protein antigen c of Streptococcus mutans to platelet aggregation

• DOI: 10.1111/j.1399-302x.2009.00521.x
• 发表时间: 2009-10-01
• 期刊: ORAL MICROBIOLOGY AND IMMUNOLOGY
• 作者: Matsumoto-Nakano, M.;Tsuji, M.;Ooshima, T.
• 通讯作者: Ooshima, T.

Defect of glucosyltransferases reduces platelet aggregation activity of Streptococcus mutans: Analysis of clinical strains isolated from oral cavities

• DOI: 10.1016/j.archoralbio.2010.03.017
• 发表时间: 2010-06-01
• 期刊: ARCHIVES OF ORAL BIOLOGY
• 影响因子: 3
• 作者: Taniguchi, N.;Nakano, K.;Ooshima, T.
• 通讯作者: Ooshima, T.