Study on molecular mechanism of oxidative stress in brain and anti-oxidant interventions

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We examined reactive oxygen radical-dependent chemiluminescent signals in ex-vivo brain slices using a novel photonic imaging method "real-time bioradiography". Results are as follows.(1) Reactive oxygen radical generation and glucose metabolism was enhanced during hypoxia-reoxygenation and hypoxia, respectively.(2) Mitochondria are suggested as major sites of reactive oxygen radical generation.(3) To develop the interventions to decelerate oxidative stress, we examined effect of calorie restriction on reactive oxygen radical generation. However, calorie restriction did not change the reactive oxygen radical generation.