The molecular mechanisms of migration of GnRH neurons and GnRH axon projection to the median eminence.

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Migration assays in coculture explants of GnRH neurons in the embryonic chick dorsal septum region demonstrated that semaphorin 3A-neuropilin 1 signaling act as a chemorepulsive cue for the migration of GnRH neurons in the forebrain. In Slit1 ; Slit2 double mutant mice, GnRH neuron migration toward the caudal region was disturbed and GnRH axon projections to the median eminence were severely reduced. It is possible that the aberrant crossing fibers in the preoptic area led to a defect of GnRH neuron migration and a disruption of GnRH axonal pathfinding as a physical barrier.