Distribution of Intraepithelial lymphocytes in the murine small intestine : The variability of the morphological property and function

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Different intestinal intraepithelial lymphocytes (IEL)subgroups (presence of granules, etc.)in different villus sites were demonstrated by morphological analysis. Granzyme B (GrB)has been proved to be involved in the induction of DNA fragmentation of epithelial cells due to IEL activation, the results suggest the possibility of a new DNA fragmentation induction mechanism different from that of previously reported perforin (Pfn)/GrB system. We also found that IELs in the front line of the intestinal defense system are highly stimulus-sensitive, thus are disposable, and, when stimulated, finally causing DNA fragmentation in the surrounding villus epithelial cells.