Tumorigenicity by TGF-βsignaling

TGF-β信号传导的致瘤性

• 批准号: 21590328
• 负责人: ITOH Susumu
• 金额: $ 2.91万
• 依托单位: Showa Pharmaceutical University (2010-2011)University of Tsukuba (2009)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590328/
• 关键词: TGF-β; Smad; がん; 血管新生; ノックアウトマウス; TMEPAI; C180RF1; 細胞増殖抑制; 発がん; TGF-beta; Tie2-Cre; C18orf1

TMEPAI gene is synergistically activated by both wnt and TGF-β signaling.C18Orf1, one of TMEPAI family, can inhibit TGF-β signaling like TMEPAI.Both TMEPAI and C18Orf1 knockout mice were generated. However, no phenotypes for both mice have been observed.The structure of blood vessels from endothelial cell-specific Smad2/3 double knockout mice seems to be fragile because the expressions of claudin 5, S1PR1 and N-cadherin are reduced in the endothelial cells from those mice.Endothelial cells from endothelial cell-specific Smad2/3 double knockout mice reveal morphological change when cells receive shear stress.

TMEPAI基因可被wnt和TGF-β信号协同激活，TMEPAI家族成员C18 Orf 1也能抑制TGF-β信号。内皮细胞特异性Smad 2/3双基因敲除小鼠的内皮细胞中claudin 5、S1 PR 1和N-cadherin的表达减少，因此血管结构似乎很脆弱。内皮细胞特异性Smad 2/3双基因敲除小鼠的内皮细胞在受到切应力时出现形态学变化。

项目成果

Transmembrane AR-Smad Trapper(TARST) family is a negative regulator of TGF-βsignaling

跨膜 AR-Smad Trapper (TARST) 家族是 TGF-β 信号传导的负调节因子

• 发表时间: 2011
• 作者: Itoh S;Maeyama K;Nakano N;Watanabe Y;Itoh F;Togawa T and Kato M
• 通讯作者: Togawa T and Kato M

概論-TGF-βファミリー研究の新しい流れ,実験医学

简介 - TGF-β家族研究、实验医学的新趋势

• 发表时间: 2010
• 作者: 宮澤恵二;伊東進
• 通讯作者: 伊東進

Regulation of TGF-β signaling by TMEPAI family

TMEPAI 家族对 TGF-β 信号传导的调节

• 发表时间: 2010
• 作者: 武田晃治;ら;Itoh S
• 通讯作者: Itoh S

Role of TMEPAI in negative feedback loop of TGF-beta signaling.

TMEPAI 在 TGF-β 信号传导负反馈环中的作用。

• 发表时间: 2009
• 作者: Kurihara Y;Kanki T;Aoki Y;Hirota Y;Saigusa T;Uchiumi T;Kang D.;井上徳光;Susumu itoh
• 通讯作者: Susumu itoh

Impairment of vascular stability by endothelial specific ablation for Smad2 and Smad3 genes

Smad2 和 Smad3 基因的内皮特异性消融损害血管稳定性

• 发表时间: 2010
• 作者: Itoh F;Itch S;Adachi T;Festing M;Weinstein M;Kato M
• 通讯作者: Kato M