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Research on early diagnosis of abnormal carbohydrate metabolism by antibody specific for AGEs

Research on early diagnosis of abnormal carbohydrate metabolism by antibody specific for AGEs
AGEs特异性抗体早期诊断碳水化合物代谢异常的研究
批准号:
21590340
负责人:
NAGAI Ryoji
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Pentosidine, one of advanced glycation end-products(AGEs), is measured by HPLC in the serum, and increased by heating in a temperature-and time-dependent manner. The increase in pentosidine formation is significantly inhibited by acidic conditions. This indicates that the level of serum pentosidine will be measured more accurately by ELISA if hydrochloric acid is added during the heating process. Furthermore, N^ω-carboxymethylarginine(CMA), acid labile AGE structure, is preferentially generated in glycated collagen. We elucidated the hot-spot of CMA formation in glycated collagen.
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DOI: 10.1093/ndt/gfr152
发表时间: 2011-11
期刊: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
影响因子: --
作者: [Jehyun Park;M. Kwon;J. Huh;W. J. Choi;L. Jeong;R. Nagai;W. Kim;Jin Kim;G. Lee;Hi-Bahl Lee]
通讯作者: Jehyun Park;M. Kwon;J. Huh;W. J. Choi;L. Jeong;R. Nagai;W. Kim;Jin Kim;G. Lee;Hi-Bahl Lee
糖による無秩序な蛋白の変性と老化
由于糖导致的蛋白质变性和老化紊乱
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [金井好克, 永井竜児]
通讯作者: 永井竜児
トマト由来の新規動脈硬化抑制化合物について
关于从西红柿中提取的一种新的动脉硬化抑制化合物
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [藤原章雄, 池田剛, 竹屋元裕, 野原稔弘, 永井竜児]
通讯作者: 永井竜児
DOI: 10.1111/j.1442-2042.2009.02259.x
发表时间: 2009-04-01
期刊: INTERNATIONAL JOURNAL OF UROLOGY
影响因子: 2.6
作者: [Matsumoto, Kenshi, Fujiwara, Yukio, Yoshida, Masaki]
通讯作者: Yoshida, Masaki
54
    Development and demonstration of a multi-objective optimization tool for high-current electron beam generation
    Establishment of evaluation criteria for food safety by AGE measurement
    • 批准号:
      24650482
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2012
    • 负责人:
      NAGAI Ryoji
    • 依托单位:
    Investigation of optimal nutritional balance based on the inhibition of S-(2-succinyl) cysteine (2SC), post-translational modification by fumarate
    • 批准号:
      24300260
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.65万
    • 财政年份:
      2012
    • 负责人:
      NAGAI Ryoji
    • 依托单位:
    Development of an asymetric optical resonator for the monochromatic gamma-ray source
    • 批准号:
      23561018
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.58万
    • 财政年份:
      2011
    • 负责人:
      NAGAI Ryoji
    • 依托单位:
    海外基金