Investigation of role of glial cells in glaucomatous optic neuropathy and searching glial cell-related treatment for glaucoma

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I clarified the following points ; Different glutamate transporters(GLT) were differently involved in glial cell-related effect on RGC. Major GLT, GLAST exerted neuroprotective effect on RGC, while GLT-1 exerted effect on promoting neuritis. Muller cells, major retinal glial cells, showed a protective effect on retinal ganglion cells(RGCs), while astrocytes in optic nerve did promoting effect of neurites. Several mRNAs influenced to RGC survival or neurite elongation were identified as key mRNAs for GLT-involved RGC effects. EGFR, Gabbr2, Agtr1a showed protective effect, while Id3、Egr1, Gja1p, App, Nr2f2 mRNAs were involved in RGC death. I developed an animal model that enables to observe axonal flow of lived rat retina.