Antitumor effect of neutrophil-derived TRAIL for oral squamous cell carcinoma

中性粒细胞来源的 TRAIL 对口腔鳞状细胞癌的抗肿瘤作用

• 批准号: 21592562
• 负责人: IWASE Masayasu
• 金额: $ 2.91万
• 依托单位: Tsurumi University (2011)Showa University (2009-2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592562/
• 关键词: TRAIL; 好中球; アポトーシス; 抗腫瘍効果; 臨床腫瘍学; OK432; インターフェロン; 分子標的治療; デスレセプター

BCG and OK432 enhanced TRAIL production and chemotaxis of neutrophils in a dose-dependent manner. Although TRAIL derived from neutrophils was insufficient cytotoxicity for squamous cell carcinoma cells, TRAIL from neutrophils possessed a priming effect for anti-tumor drugs or irradiation-induce cytotoxicity. These results are suggested that a combination of OK-432 and conventional therapy such as anti-tumor drugs and irradiation is a new anti-tumor strategy.

BCG和OK 432以剂量依赖性方式增强中性粒细胞的TRAIL产生和趋化性。虽然来源于中性粒细胞的TRAIL对鳞状细胞癌细胞的细胞毒性不足，但来源于中性粒细胞的TRAIL具有抗肿瘤药物或辐射诱导的细胞毒性的引发效应。这些结果表明，OK-432与常规治疗如抗肿瘤药物和放射治疗相结合是一种新的抗肿瘤策略。

项目成果

Enhanced susceptibility to TRAIL-mediated apoptosis in oral squamous cell carcinoma cells through down-regulation of cellular FLIP

通过下调细胞 FLIP 增强口腔鳞状细胞癌细胞对 TRAIL 介导的细胞凋亡的敏感性

• 发表时间: 2007
• 作者: Iwase M;Takaoka S;Uchida M;Yoshiba S;Shirota T;Hatori M;Shintani S.
• 通讯作者: Shintani S.

Proteasome inhibitor sensitizes oral squamous cell carcinoma cells to TRAIL-mediated apoptosis

蛋白酶体抑制剂使口腔鳞状细胞癌细胞对 TRAIL 介导的细胞凋亡敏感

• 发表时间: 2011
• 期刊: Oncology Reports
• 影响因子: 4.2
• 作者: SAYAKA YOSHIBA;MASAYASU IWASE;SAYAKA TAKAOKA;MAKIKO UCHIDA;YUJI KURIHARA;HITOSGI WATANABE;SATORU SHINTANI
• 通讯作者: SATORU SHINTANI

Protease inhibitor sensitizes oral squamous cell carcinoma cells to TRAIL-mediated apotpsis.

蛋白酶抑制剂使口腔鳞状细胞癌细胞对 TRAIL 介导的细胞凋亡敏感。

• 发表时间: 2011
• 期刊: Oncol Rep
• 影响因子: 4.2
• 作者: Yoshiba S;Iwase K;et al
• 通讯作者: et al