Novel roles of adipocytes in the mammary gland development and breast cancer progression, and involvement of adipokines in the roles

脂肪细胞在乳腺发育和乳腺癌进展中的新作用，以及脂肪因子在这些作用中的参与

• 批准号: 21380177
• 负责人: KIMURA Kazuhiro
• 金额: $ 12.4万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21380177/
• 关键词: 乳腺; 乳癌; 脂肪細胞; エストロゲン; プロラクチン; レプチン; HGF; NGF; 乳腺発達; プロゲステロン; STAT; 母性行動; ストレス; 脳機能; 肥満; 泌乳

The mammary gland develops in subcutaneous adipose tissue in the post natal period, and adipocytes function as a nursing cell for epithelial cells. With hypertrophy of adipocytes, ductal development of mammary gland in non-pregnant mice was impaired. Hypertrophy of adipocytes also delayed side-branch formation from the duct in the early phase of pregnancy, and acinar formation and its maturation in the mid-and late phase of pregnancy. Hypertrophy of adipocytes caused hyper-leptinemia, and leptin mimicked some effects by hypertrophy of adipocytes both in vivo and in vitro. Therefore, it was suggested that hypertrophy of adipocytes suppressed mammary gland development and leptin partly played a role in the suppression.

乳腺在出生后的皮下脂肪组织中发育，脂肪细胞作为上皮细胞的哺育细胞。随着脂肪细胞的肥大，非妊娠小鼠乳腺导管发育受损。脂肪细胞的肥大在妊娠早期延缓了导管侧枝的形成，在妊娠中后期延缓了腺泡的形成和成熟。脂肪细胞肥大会导致高瘦素血症，而瘦素在体内和体外都通过脂肪细胞肥大来模拟某些效应。因此，脂肪细胞的肥大抑制了乳腺的发育，瘦素在抑制乳腺发育中起部分作用。

项目成果

Retinol binding protein 4 in dairy cows: its presence in colostrum and alteration in plasma during fasting, inflammation, and the peripartum period

• DOI: 10.1017/s0022029909990276
• 发表时间: 2010-02-01
• 期刊: JOURNAL OF DAIRY RESEARCH
• 影响因子: 2.1
• 作者: Eldaim, Mabrouk A. Abd;Kamikawa, Akihiro;Kimura, Kazuhiro
• 通讯作者: Kimura, Kazuhiro

Effects of retinoic acid on lipid accumulation in bovine and mouse adipocytes are inverted dependently on glucose concentration in the cultures

视黄酸对牛和小鼠脂肪细胞脂质积累的影响取决于培养物中的葡萄糖浓度

• 发表时间: 2009
• 作者: Abd El Daim Mabrouk;Mohamed Ahmed;岡松優子,上川昭博,寺尾晶,木村和弘
• 通讯作者: 岡松優子,上川昭博,寺尾晶,木村和弘

Possible involvement of uncoupling protein 1 in appetite control by leptin

• DOI: 10.1258/ebm.2011.011143
• 发表时间: 2011-11-01
• 期刊: EXPERIMENTAL BIOLOGY AND MEDICINE
• 影响因子: 3.2
• 作者: Okamatsu-Ogura, Yuko;Nio-Kobayashi, Junko;Saito, Masayuki
• 通讯作者: Saito, Masayuki

食餌性肥満が乳腺発達に及ぼす影響

饮食肥胖对乳腺发育的影响

• 发表时间: 2009
• 期刊: 肥満研究
• 作者: 上川昭博;鈴木千春;山本敦子;木村和弘
• 通讯作者: 木村和弘

Diet-induced obesity disrupts postnatal and pregnancy-associated mammary gland development in mice : possible roles of leptin

饮食引起的肥胖会扰乱小鼠产后和妊娠相关的乳腺发育：瘦素的可能作用

• 发表时间: 2010
• 作者: Kimura;K.;et al.
• 通讯作者: et al.