The estabIishment of well-differentiated corneal epithelial cell line and the analysis of mechanism for corneal epithelial differentiation
The estabIishment of well-differentiated corneal epithelial cell line and the analysis of mechanism for corneal epithelial differentiation
批准号:
19791271
负责人:
KIMURA Kazuhiro
金额:
$2.36万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
角膜上皮は、角膜表層でバリアーとして重要な働きをしている。これまで継代可能な角膜上皮細胞には正常なGap Junction(GJ)が存在せず、細胞-細胞間での分子の交換がなされていない。つまり、統合的な分化形質を保持した培養角膜上皮細胞は、未だ存在しないことを示唆している。そこで、GJ構成分子の一つであるコネキシン43に着目し、正常なGJ機能を有し,角膜上皮分子マーカーの発現を維持した Human コネキシン43安定発現角膜上皮細胞株の樹立に成功した。
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Cytokine, Chemokine, and Adhesion Molecule Expression Mediated by Mitogen-Activated Protein Kinases in Human Corneal Fibroblasts Exposed to Poly(I:C).
暴露于 Poly(I:C) 的人角膜成纤维细胞中由丝裂原激活蛋白激酶介导的细胞因子、趋化因子和粘附分子表达。
DOI:
--
发表时间:
2008
期刊:
Invest Ophthalmol Vis Sci 49
影响因子:
--
作者:
[Liu Y, Kimura K]
通讯作者:
Kimura K
角膜線維芽細胞でのPoly(I:C)によるサイトカイン産生への作用
Poly(I:C) 对角膜成纤维细胞细胞因子产生的影响
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Nishiguchi KM, Kaneko H, Nakamura M, Kachi S, Terasaki H, 木村和博,劉洋,柳井亮二,近間泰一郎,西田輝夫, Kaneko H, 木村和博]
通讯作者:
木村和博
IL-1βによる角膜上皮細胞間接着構造への作用.
IL-1β对角膜上皮细胞间粘附结构的影响。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Kaneko H, Nishiguchi KM, Nakamura M, Kachi S, Terasaki H, 木村和博,寺西慎一郎,折田朋子,西田輝夫]
通讯作者:
木村和博,寺西慎一郎,折田朋子,西田輝夫
DOI:
10.1167/iovs.07-0419
发表时间:
2008-02-01
期刊:
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
影响因子:
4.4
作者:
[Kimura, Kazuhiro, Teranishi, Shinichiro, Nishida, Teruo]
通讯作者:
Nishida, Teruo
DOI:
10.1167/iovs.08-2606
发表时间:
2009-02-01
期刊:
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
影响因子:
4.4
作者:
[Kimura, Kazuhiro, Teranishi, Shinichiro, Nishida, Teruo]
通讯作者:
Nishida, Teruo
共 23 条
The inhibition of subretinal fibrosis by specific retinoic receptor ligands
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批准号:17K11451
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2017
-
负责人:KIMURA Kazuhiro
-
依托单位:
iPS cell cells for cardiac electrical regeneration
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批准号:15K15307
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2015
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负责人:KIMURA Kazuhiro
-
依托单位:
The mechanism of inhibitional effect to subretinal fibrosis by nuclear receptor system
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批准号:26462663
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2014
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负责人:KIMURA Kazuhiro
-
依托单位:
Development of new drugs based on molecular mechanism for infectious corneal ulcer
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批准号:23592572
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2011
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负责人:KIMURA Kazuhiro
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依托单位:
Novel roles of adipocytes in the mammary gland development and breast cancer progression, and involvement of adipokines in the roles
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批准号:21380177
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.4万
-
财政年份:2009
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负责人:KIMURA Kazuhiro
-
依托单位:
The analysis of mechanism for corneal ulceration and the development of new drugs
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批准号:21791687
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
-
财政年份:2009
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负责人:KIMURA Kazuhiro
-
依托单位:
Life extension of ferritic creep resistant steel by reduced dislocation density
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批准号:20360323
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.9万
-
财政年份:2008
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负责人:KIMURA Kazuhiro
-
依托单位:
Role of adipokines and inflammatory cytokines in the regulation of the mammary gland development and the pathogenesis of mastitis and breast cancer
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批准号:18380172
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.6万
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财政年份:2006
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负责人:KIMURA Kazuhiro
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依托单位:
Cellular and molecular mechanisms of the UCPs-dependent metabolic control and its patho-physiological relevance
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批准号:15580252
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2003
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负责人:KIMURA Kazuhiro
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依托单位:
Potential Demand of the Elderly and Disabled and Alternative Transport Systems for Them
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批准号:15560453
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.92万
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财政年份:2003
-
负责人:KIMURA Kazuhiro
-
依托单位:
Evaluation and systematization for local environment which were formed by the agriculture, forestry and livestock industry in mountainous rural area
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批准号:15208022
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$17.22万
-
财政年份:2003
-
负责人:KIMURA Kazuhiro
-
依托单位:
Influences of Compact Structure of a City on Peoples Activities and Travel Behavior
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批准号:12650524
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:2000
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负责人:KIMURA Kazuhiro
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依托单位:
Role of uncoupling protein 2 in the regulation of bioenergetics and metabolism in the liver.
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批准号:12660265
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
-
财政年份:2000
-
负责人:KIMURA Kazuhiro
-
依托单位:
Agricultural landscape changing due to social and economical structure change and formation process for safety environment in the mountainous rural village in the area of Japan's Southern Alps
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批准号:12660217
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2000
-
负责人:KIMURA Kazuhiro
-
依托单位:
Expression of vascular endothelial cell growth factor and regeneration of hepatic endothelial cells during liver regeneration.
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批准号:09660310
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
-
财政年份:1997
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负责人:KIMURA Kazuhiro
-
依托单位:
Modeling of Driver's Eye Movement and Evaluation of Traffic Environment
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批准号:08650619
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1996
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负责人:KIMURA Kazuhiro
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依托单位:
Land Consolidation and Animal Introduction for Utilization of Waste Land of Paddy Fields in Steep Sloping Area
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批准号:08660288
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1996
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负责人:KIMURA Kazuhiro
-
依托单位:
Safety and Efficiency for Weeding Work and Form of Levee Slope on Paddy Field in a Steep Sloping Area
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批准号:04660251
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
-
财政年份:1992
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负责人:KIMURA Kazuhiro
-
依托单位:
海外基金