The analysis of mechanism for corneal ulceration and the development of new drugs

角膜溃疡机制分析及新药开发

• 批准号: 21791687
• 负责人: KIMURA Kazuhiro
• 金额: $ 2.75万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791687/
• 关键词: 角膜潰瘍; コラーゲン分解; 病原微生物; 角膜; 潰瘍; コラーゲン

Corneal ulceration results from the destruction of collagen fibrils in the stroma. Histological observations have revealed that corneal keratocytes, fibroblasts and infiltrated leukocytes are present at corneal tissue affected by ulceration. Corneal fibroblasts have an important role in the formation of corneal ulceration.In responses to lipopolysaccharide (LPS), polyinosinic-polycytidylic acid [poly(I:C)], and zymosan as surrogates for bacteria, viruses, and fungi, the cells produces various cytokines, chemokines and matrix metalloproteinases.

角膜溃疡是基质中胶原纤维破坏的结果。组织学观察显示，角膜角膜细胞、成纤维细胞和浸润的白细胞存在于受溃疡影响的角膜组织中。角膜成纤维细胞在角膜溃疡的形成中起重要作用，其对细菌、病毒和真菌的替代物脂多糖（LPS）、聚肌胞苷酸（poly（I：C））和酵母多糖的反应产生多种细胞因子、趋化因子和基质金属蛋白酶。

项目成果

角膜上皮細胞におけるTNF-αによるOccludin,β-cateninのチロシンリン酸化作用

角膜上皮细胞中 TNF-α 对 Occludin 和 β-catenin 的酪氨酸磷酸化

• 发表时间: 2009
• 作者: 木村和博;寺西慎一郎;西田輝夫
• 通讯作者: 西田輝夫

Interleukin-1β-Induced Disruption of Barrier Function in Cultured Human Corneal Epithelial Cells

• DOI: 10.1167/iovs.08-2606
• 发表时间: 2009-02-01
• 期刊: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
• 影响因子: 4.4
• 作者: Kimura, Kazuhiro;Teranishi, Shinichiro;Nishida, Teruo
• 通讯作者: Nishida, Teruo

Device for cataract analysis: development and relevance to cataract surgery.

白内障分析设备：发展及其与白内障手术的相关性。

• 发表时间: 2010
• 期刊: J Cataract Refract Surg 36
• 作者: Chikamoto N;Fujitsu Y;Kimura K;Nishida T;Araki T.
• 通讯作者: Araki T.

Role of Formation of an ERK-FAK-Paxillin Complex in Migration of Human Corneal Epithelial Cells during Wound Closure In Vitro

• DOI: 10.1167/iovs.08-2534
• 发表时间: 2009-12-01
• 期刊: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
• 影响因子: 4.4
• 作者: Teranishi, Shinichiro;Kimura, Kazuhiro;Nishida, Teruo
• 通讯作者: Nishida, Teruo

Quantitative Analysis of the Effects of Extracellular Matrix Proteins on Membrane Dynamics Associated with Corneal Epithelial Cell Motility

• DOI: 10.1167/iovs.09-4380
• 发表时间: 2010-09-01
• 期刊: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
• 影响因子: 4.4
• 作者: Kimura, Kazuhiro;Kawano, Sumihiro;Nishida, Teruo
• 通讯作者: Nishida, Teruo