The analysis of mechanism for corneal ulceration and the development of new drugs
The analysis of mechanism for corneal ulceration and the development of new drugs
批准号:
21791687
负责人:
KIMURA Kazuhiro
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
角膜溃疡是基质中胶原纤维破坏的结果。组织学观察显示,角膜角膜细胞、成纤维细胞和浸润的白细胞存在于受溃疡影响的角膜组织中。角膜成纤维细胞在角膜溃疡的形成中起重要作用,其对细菌、病毒和真菌的替代物脂多糖(LPS)、聚肌胞苷酸(poly(I:C))和酵母多糖的反应产生多种细胞因子、趋化因子和基质金属蛋白酶。
英文摘要
Corneal ulceration results from the destruction of collagen fibrils in the stroma. Histological observations have revealed that corneal keratocytes, fibroblasts and infiltrated leukocytes are present at corneal tissue affected by ulceration. Corneal fibroblasts have an important role in the formation of corneal ulceration.In responses to lipopolysaccharide (LPS), polyinosinic-polycytidylic acid [poly(I:C)], and zymosan as surrogates for bacteria, viruses, and fungi, the cells produces various cytokines, chemokines and matrix metalloproteinases.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
角膜上皮細胞におけるTNF-αによるOccludin,β-cateninのチロシンリン酸化作用
角膜上皮细胞中 TNF-α 对 Occludin 和 β-catenin 的酪氨酸磷酸化
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[木村和博, 寺西慎一郎, 西田輝夫]
通讯作者:
西田輝夫
DOI:
10.1167/iovs.08-2606
发表时间:
2009-02-01
期刊:
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
影响因子:
4.4
作者:
[Kimura, Kazuhiro, Teranishi, Shinichiro, Nishida, Teruo]
通讯作者:
Nishida, Teruo
Device for cataract analysis: development and relevance to cataract surgery.
白内障分析设备:发展及其与白内障手术的相关性。
DOI:
--
发表时间:
2010
期刊:
J Cataract Refract Surg 36
影响因子:
--
作者:
[Chikamoto N, Fujitsu Y, Kimura K, Nishida T, Araki T.]
通讯作者:
Araki T.
DOI:
10.1167/iovs.08-2534
发表时间:
2009-12-01
期刊:
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
影响因子:
4.4
作者:
[Teranishi, Shinichiro, Kimura, Kazuhiro, Nishida, Teruo]
通讯作者:
Nishida, Teruo
DOI:
10.1167/iovs.09-4380
发表时间:
2010-09-01
期刊:
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
影响因子:
4.4
作者:
[Kimura, Kazuhiro, Kawano, Sumihiro, Nishida, Teruo]
通讯作者:
Nishida, Teruo
共 12 条
The inhibition of subretinal fibrosis by specific retinoic receptor ligands
-
批准号:17K11451
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2017
-
负责人:KIMURA Kazuhiro
-
依托单位:
iPS cell cells for cardiac electrical regeneration
-
批准号:15K15307
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2015
-
负责人:KIMURA Kazuhiro
-
依托单位:
The mechanism of inhibitional effect to subretinal fibrosis by nuclear receptor system
-
批准号:26462663
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2014
-
负责人:KIMURA Kazuhiro
-
依托单位:
Development of new drugs based on molecular mechanism for infectious corneal ulcer
-
批准号:23592572
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2011
-
负责人:KIMURA Kazuhiro
-
依托单位:
Novel roles of adipocytes in the mammary gland development and breast cancer progression, and involvement of adipokines in the roles
-
批准号:21380177
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.4万
-
财政年份:2009
-
负责人:KIMURA Kazuhiro
-
依托单位:
Life extension of ferritic creep resistant steel by reduced dislocation density
-
批准号:20360323
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.9万
-
财政年份:2008
-
负责人:KIMURA Kazuhiro
-
依托单位:
The estabIishment of well-differentiated corneal epithelial cell line and the analysis of mechanism for corneal epithelial differentiation
-
批准号:19791271
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.36万
-
财政年份:2007
-
负责人:KIMURA Kazuhiro
-
依托单位:
Role of adipokines and inflammatory cytokines in the regulation of the mammary gland development and the pathogenesis of mastitis and breast cancer
-
批准号:18380172
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.6万
-
财政年份:2006
-
负责人:KIMURA Kazuhiro
-
依托单位:
Cellular and molecular mechanisms of the UCPs-dependent metabolic control and its patho-physiological relevance
-
批准号:15580252
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.37万
-
财政年份:2003
-
负责人:KIMURA Kazuhiro
-
依托单位:
Potential Demand of the Elderly and Disabled and Alternative Transport Systems for Them
-
批准号:15560453
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.92万
-
财政年份:2003
-
负责人:KIMURA Kazuhiro
-
依托单位:
Evaluation and systematization for local environment which were formed by the agriculture, forestry and livestock industry in mountainous rural area
-
批准号:15208022
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$17.22万
-
财政年份:2003
-
负责人:KIMURA Kazuhiro
-
依托单位:
Influences of Compact Structure of a City on Peoples Activities and Travel Behavior
-
批准号:12650524
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.41万
-
财政年份:2000
-
负责人:KIMURA Kazuhiro
-
依托单位:
Role of uncoupling protein 2 in the regulation of bioenergetics and metabolism in the liver.
-
批准号:12660265
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2000
-
负责人:KIMURA Kazuhiro
-
依托单位:
Agricultural landscape changing due to social and economical structure change and formation process for safety environment in the mountainous rural village in the area of Japan's Southern Alps
-
批准号:12660217
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2000
-
负责人:KIMURA Kazuhiro
-
依托单位:
Expression of vascular endothelial cell growth factor and regeneration of hepatic endothelial cells during liver regeneration.
-
批准号:09660310
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:1997
-
负责人:KIMURA Kazuhiro
-
依托单位:
Modeling of Driver's Eye Movement and Evaluation of Traffic Environment
-
批准号:08650619
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.47万
-
财政年份:1996
-
负责人:KIMURA Kazuhiro
-
依托单位:
Land Consolidation and Animal Introduction for Utilization of Waste Land of Paddy Fields in Steep Sloping Area
-
批准号:08660288
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.47万
-
财政年份:1996
-
负责人:KIMURA Kazuhiro
-
依托单位:
Safety and Efficiency for Weeding Work and Form of Levee Slope on Paddy Field in a Steep Sloping Area
-
批准号:04660251
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.28万
-
财政年份:1992
-
负责人:KIMURA Kazuhiro
-
依托单位:
海外基金