Studies of the roles of pituitary transcription factors for pituitary development and progenitor cells
Studies of the roles of pituitary transcription factors for pituitary development and progenitor cells
批准号:
21380184
负责人:
KATO Yukio
金额:
$12.4万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
本研究旨在了解同源异型转录因子如何发育垂体前叶,并提供产生多种激素和再生垂体细胞的能力。通过分子生物学、细胞生物学和免疫组织化学等方法,我们证实了垂体特异性转录因子PROP 1和新的垂体因子PRX 1/PRX 2在垂体器官发生过程中是不可缺少的。阐明其分子功能尚待进一步研究。
英文摘要
This study aimed to understand how homeotic transcription factors develop anterior pituitary and provide abilities to produce several hormones and regenerate hormone-producing cells throughout the life. By several approaches of molecular biology, cell biology and immunohistochemistry, we demonstrated that a pituitary specific transcription factor PROP1 and novel pituitary factors PRX1/PRX2 are indispensable for the pituitary organogenesis. To clarify the molecular functions are remained to be resolved in near future.
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下垂体におけるホルモンを合成しないS100b陽性細胞の分化能について
关于垂体中不合成激素的S100b阳性细胞的分化潜力
DOI:
--
发表时间:
2010
期刊:
明治大学農研報
影响因子:
--
作者:
[大砂まるみ, 井上金治, 加藤幸雄]
通讯作者:
加藤幸雄
DOI:
10.1016/j.mce.2009.10.006
发表时间:
2010-02-05
期刊:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
影响因子:
4.1
作者:
[Kato, Yukio, Kimoto, Fuyuko, Kato, Takako]
通讯作者:
Kato, Takako
下垂体におけるリムホメオドメイン型転写因子LHX2とLHX3の機能解析
垂体rim同源域转录因子LHX2和LHX3的功能分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[佐野嘉哉, 石川晶雄, 諏佐崇生, 北原康輔, 加藤たか子, 加藤幸雄]
通讯作者:
加藤幸雄
TtT/GF細胞における下垂体新規転写因子Prx2のプロモーター解析
TtT/GF细胞中垂体新型转录因子Prx2的启动子分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[石川晶雄, 諏佐崇生, 加藤たか子, 加藤幸雄]
通讯作者:
加藤幸雄
インターフェロン"(IFN")によるmyxovirus resistance 1(Mx1)偽遺伝子のゴナドトロフ細胞株(LβT2)における転写調節
促性腺激素细胞系 (LβT2) 中干扰素 (IFN) 对粘病毒抗性 1 (Mx1) 假基因的转录调节
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[寺島涼太, 米澤智洋, 久留主志朗, 加藤たか子, 加藤幸雄, 汾陽光盛]
通讯作者:
汾陽光盛
共 75 条
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Development of triple-target antitumor drugs recognized by oligopeptide transporters
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Digital Archives and Early Modern English Theatre: The Network of Playhouses, Players, and Printing-houses
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项目类别:Grant-in-Aid for Scientific Research (B)
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财政年份:2011
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The molecular mechanism by which transcriptional factor DEC1 modulates circadian rhythms of blood pressure.
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批准号:23390423
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.4万
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财政年份:2011
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Serum-free medium for dental regenerative tissue engineering
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Research of transporter-adaptor network as target of drug effect and toxicity
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Studies for mechanisms of gonadotropin gene regulation with novel pituitary transcription factors
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批准号:18380177
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项目类别:Grant-in-Aid for Scientific Research (B)
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财政年份:2006
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Roles of transporter adaptors as regulatory mechanism for drug absorption and disposition
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资助金额:$2.53万
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财政年份:2006
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依托单位:
Molecular basis for quantitative prediction of drug-drug interaction at excretion process
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批准号:16590108
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Molecular clock and bone metabolism : stimulation of osteoblast and chondrocyte differentiation by novel clock genes
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.41万
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财政年份:2003
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负责人:KATO Yukio
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依托单位:
HOMEOTIC TRANSCRIPTION FACTORS THAT BIND TO FOLLICLE -STIMULATING HORMONE SUBUNITE GENE
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批准号:12557087
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Regeneration of cartilage and bone by transplantation of autologous cells transfected with chondrocyte-inducible genes
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财政年份:2000
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负责人:KATO Yukio
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依托单位:
HOMEOTIC TRANSCRIPTION FACTORS THAT BIND TO FOLLICLE-STIMULATING HORMONE SUBUNITE GENE
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项目类别:Grant-in-Aid for Scientific Research (B)
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Pharmacokinetic analysis of the injured organ-specific targeting of hepatocyte growth factor
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财政年份:1999
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依托单位:
Role of PTH and PTH-related peptide in skeletal development
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批准号:10044293
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资助金额:$5.5万
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PRODUCTION OF RECOMBINANT GONADOTROPINS (FSH AND LH) AND APPLICATION FOR CONTROL IN REPRODUCTION
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负责人:KATO Yukio
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Biomaterial having active sites of collagen-binding adhesion molecules (CMP and RGD-CAP)
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批准号:09557146
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Molecular biological studies on regulators of endochondral bone formation
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Cartilage-disruption factor involved in Kashin-Beck disease
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批准号:08044293
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