Study for the determination of cell fates by NotchL as environment factor

干细胞(ES、iPS或组织特异性干细胞)知识的进步使再生医学得到了显著的改进。然而，如果没有合适的环境，这些干细胞就不能分化为有功能的成熟细胞。因此，对环境因素的控制对于各种组织的再生是必要的。在这项研究中，我们将Notch配体作为一个环境因子，并研究它们对淋巴细胞或胰腺发育的生理意义。

Advances in the knowledge of the stem cells ; ES, iPS or tissue-specific stem cells, have allowed the significant improvement of regenerative medicine. However, these stem cells cannot differentiate into functional mature cells without an appropriate environment. Thus, the manipulation of the environment factors is necessary for the regeneration at various tissues. In this study, we have focused on Notch ligands as an environment factor, and examine their physiological significances for the development of lymphocytes or pancreas.