Analysis of immunological synapse in physiological condition

当T细胞识别抗原提呈细胞上的抗原时，它们开始黏附并产生T细胞抗原受体(TCR)微簇(TCR-MCs)，这是启动T细胞活化的单位。TCR-MC向界面中心移动，形成免疫突触。我们发现TCR-MCs的转运依赖于微管运动和动力蛋白，并负向调节T细胞的激活。这些观察是基于对生理刺激条件下产生的TCR-MC的定量分析。

When T cells recognize antigen on antigen.presenting cells, they start adhere and generate T cell antigen receptors (TCR) microclusters (TCR-MCs) which is a unit for starting T cell activation. The TCR-MCs move toward the center of the interface and form immunological synapse. We revealed and published that the transportation of TCR-MCs depends on microtubule motor, dynein and negatively regulate T cell activation. These observation were based on the quantitative analysis of TCR-MCs generated under physiological stimulus conditions.