Effects of sex hormones on the pathogenesis of nonalcoholic steatohepatitis (NASH)

NAFLD患者外周血单个核细胞(PBMC)G蛋白偶联受体30(GPR30)信使RNA的表达明显高于正常对照组。雌激素受体(ER)α与瘦素水平呈正相关。此外，ERα与体重指数呈正相关。另一方面，去卵巢小鼠易发生肝脏脂肪变性、胰岛素抵抗和高脂饮食引起的ALT升高。提示雌激素受体表达和雌激素缺乏可能参与了NASH的发病机制。

The expression of messenger RNA for G-protein-coupled receptor 30 (GPR30) was significantly increased in peripheral blood mononuclear cells (PBMC) from patients with NAFLD compared with PBMC from healthy controls. Other, there was a positive correlation between estrogen receptor (ER) α and the levels of leptin. Moreover, positive correlation was observed between ER α and body mass index. On the other hand, ovariectomized mice were predisposed to liver steatosis, insulin resistance and elevation of ALT by high-fat diet. These results indicated that estrogen receptor expression and lack of estrogen might contribute to the pathogenesis of NASH.