Role of Atg5-dependent autophagy in innate immunity of epidermal keratinocytes

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Autophagy is a mechanism to degrade selective cellular components. Since autophagy is a mechanism degrading the intracellular components during starvation, autophagy may play an essential role in clearance of intracellular pathogens. The purpose of this study is to clarify the role of keratinocyte autophagy in innate immunity. Differentiation and starvation induced autophagy in cultured keratinocytes. Stimulation of Toll-like receptor ligands also induced autophagy, indicating that autophagy play an important role in epidermal innate immunity. The expression of LC3 was not altered in Atg5 KO mouse epidermis.