Behavior of Bone Marrow-derived Cells Following in vivo Transplantation

体内移植后骨髓来源细胞的行为

• 批准号: 22500388
• 负责人: TAGUCHI Osamu
• 金额: $ 2.33万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500388/
• 关键词: 実験動物技術; 骨髄細胞; 臓器再生; 間質上皮相互作用; マウス; 移植; 骨髄移植; 放射線照射; 再生; 間質細胞; 上皮; 上皮・間質相互作用; GFP; scid; x線照射; FACS; CD45

Following injection of green fluorescent protein positive (GFP^+) bone marrow (BM) cells into lethally irradiated wild-type mice, the organs of the recipient mice (BM transplantation [BMT] mice) were regenerated . The maintenance of epithelial structure and function is controlled stromal cells. In BMT mice, GFP^+ stromal cells were regenerated fairly rapidly indicating that BM-derived stromal cells play a pivotal role in epithelial renewal and are crucial for maintaining organ structure and function. BM-derived cells in the periphery possess a special “key” to return to the BM and then to migrate to various organs to become resident cells.

在将绿色荧光蛋白阳性（GFP^+）骨髓（BM）细胞注射到致死辐射的野生型小鼠中之后，受体小鼠（BM移植[BMT]小鼠）的器官再生。上皮结构和功能的维持是由基质细胞控制的。在BMT小鼠中，GFP^+基质细胞再生相当迅速，表明BM衍生的基质细胞在上皮更新中起关键作用，并且对于维持器官结构和功能至关重要。外周的BM衍生细胞拥有一把特殊的“钥匙”，可以返回BM，然后迁移到各个器官，成为常驻细胞。

项目成果

Antitumor activity of an interleukin-2 monoclonal antibody in a murine osteosarcoma transplantation model

IL-2 单克隆抗体在小鼠骨肉瘤移植模型中的抗肿瘤活性

• 发表时间: 2012
• 期刊: Anticancer Res
• 影响因子: 2
• 作者: Kohyama K;Sugiura H;Kozawa E;Wasa J;Yamada K;Nishioka A;Kamei Y;Taguchi O
• 通讯作者: Taguchi O

Zoledronate sensitizes neuroblastoma-derived tumor-initiating cells to cytolysis mediated by human γδ T cells.

Zoledronate 使神经母细胞瘤来源的肿瘤起始细胞对人 γδ T 细胞介导的细胞溶解敏感。

• 发表时间: 2012
• 期刊: J Immunother.
• 作者: 園田貴丈;Samatchaya Boonchawalit;田中和樹;丸田康広;Kristel Ramirez;桑田岳夫;松下修三;Nishio N.
• 通讯作者: Nishio N.

Cellular Imaging Using Equivalent Cross-Relaxation Rate Technique in Rabbit VX-2 Tumor Model.

• DOI: 10.4137/cin.s7833
• 发表时间: 2011
• 期刊: Cancer informatics
• 影响因子: 2
• 作者: Nishiofuku H;Matsushima S;Taguchi O;Inaba Y;Yamaura H;Sato Y;Tanaka T;Kichikawa K
• 通讯作者: Kichikawa K

Promotion and maintenance of leukemia by ERG

• DOI: 10.1182/blood-2010-11-320515
• 发表时间: 2011-04-07
• 期刊: BLOOD
• 影响因子: 20.3
• 作者: Tsuzuki, Shinobu;Taguchi, Osamu;Seto, Masao
• 通讯作者: Seto, Masao

Suppression of tumour metastasis in a murine osteosarcoma model with anti-CD25 monoclonal antibody treatment.

用抗 CD25 单克隆抗体治疗抑制小鼠骨肉瘤模型中的肿瘤转移。

• 发表时间: 2011
• 期刊: Anticancer Res.
• 作者: Wasa J;Sugiura H;Kozawa E;Kohyama K;Yamada K;Taguchi O.
• 通讯作者: Taguchi O.