Behavior of Bone Marrow-derived Cells Following in vivo Transplantation

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Following injection of green fluorescent protein positive (GFP^+) bone marrow (BM) cells into lethally irradiated wild-type mice, the organs of the recipient mice (BM transplantation [BMT] mice) were regenerated . The maintenance of epithelial structure and function is controlled stromal cells. In BMT mice, GFP^+ stromal cells were regenerated fairly rapidly indicating that BM-derived stromal cells play a pivotal role in epithelial renewal and are crucial for maintaining organ structure and function. BM-derived cells in the periphery possess a special “key” to return to the BM and then to migrate to various organs to become resident cells.