Histochemical studies on the expression patterns and dynamical changes of carbohydrates

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More than fifty kinds of lectins and sugar-specific monoclonal antibodies were histochemically applied to various kinds of human and mouse tissue specimens. Organ-specific distribution of sugar moieties were demonstrated on both parenchymal cells and vascular endothelial cells. Specific distribution of endothelial cell surface carbohydrates might be an important clue to explain the mechanisms of organ-specific cancer metastasis. Specific distribution of glycolipids were also demonstrated on rat cerebrum, small intestine and kidney under various pathological states including diabetes. Histochemical approaches revealed important aspects of the dynamic changes of sugar expression on various tissues and cells.