Identification of the responsible genes on 8p involved in themalignant transformation of the precancerous lesions in the pancreas .

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Genomic region, which is frequently lost in the process of malignant transformation of pancreatic precancerous lesions was clarified. Furthermore, the responsible gene located on this region was identified. This gene was shown to function as a tumor suppressor gene in pancreatic cancer by the finding that the introduction of this gene into pancreatic cancer cells had induced their cell cycle arrest followed by the decreased proliferation. It is expected in future that this gene and the related molecules can become a new diagnostic and therapeutic target of the pancreatic cancer .