Identification of the responsible genes on 8p involved in themalignant transformation of the precancerous lesions in the pancreas .

鉴定8p上参与胰腺癌前病变恶变的相关基因。

• 批准号: 22590335
• 负责人: HIJIYA Naoki
• 金额: $ 2.91万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590335/
• 关键词: 膵癌; がん抑制遺伝子; 増殖; 癌抑制遺伝子; 分子標的剤; 細胞株; アレイCGH; 網羅的発現解析

Genomic region, which is frequently lost in the process of malignant transformation of pancreatic precancerous lesions was clarified. Furthermore, the responsible gene located on this region was identified. This gene was shown to function as a tumor suppressor gene in pancreatic cancer by the finding that the introduction of this gene into pancreatic cancer cells had induced their cell cycle arrest followed by the decreased proliferation. It is expected in future that this gene and the related molecules can become a new diagnostic and therapeutic target of the pancreatic cancer .

阐明了胰腺癌前病变恶变过程中经常丢失的基因组区域。此外，还鉴定了位于该区域的致病基因。该基因被证明在胰腺癌中具有肿瘤抑制基因的功能，因为该基因被引入胰腺癌细胞后导致其细胞周期停滞，随后细胞增殖减少。该基因及其相关分子有望成为胰腺癌新的诊断和治疗靶点。

项目成果

腎淡明細胞癌転移予測因子としての9p24.1-p13.3 loss の可能性

9p24.1-p13.3 缺失作为肾透明细胞癌转移预测因子的可能性

• 发表时间: 2012
• 作者: 成松 隆弘;松浦 恵子;泥谷 直樹;中田 知里;井上 享;野村 威雄;佐藤文憲;瀬戸 加大;三股 浩光;守山 正胤
• 通讯作者: 守山 正胤

Peripancreatic strandsappearance in pancreatic body and tail carcinoma: evaluation by multi-detector CT with pathological correlation

胰体尾部癌的胰周线外观：多排 CT 评估与病理相关性

• DOI: 10.1007/s00261-011-9803-0
• 发表时间: 2012
• 期刊: Abdom Imaging
• 作者: Matsumoto S;Mori H;Kiyonaga M;SaiM;Yamada Y;Hijiya N;Shibata K;OhtaM;Kitano S;Takaki H;Fukuzawa K;Yonemasu H
• 通讯作者: Yonemasu H

Invasive carcinomas originating from intraductal papillary mucinous neoplasms of the pancreas : conspicuity and primary sites of the solid masses on triple-phase dynamic CT imaging.

源自胰腺导管内乳头状粘液性肿瘤的侵袭性癌：三相动态 CT 成像上实性肿块的显着性和原发部位。

• 发表时间: 2010
• 期刊: Abdominal Imaging
• 作者: Ogasawara N;Kojima T;Go M;Ohkuni T;Koizumi J;Kamekura R;Masaki T;Murata M;Tanaka S,Fuchimoto J;Himi T;Sawada N;Yamada Y
• 通讯作者: Yamada Y

腎淡明細胞癌におけるmiR-210 の過剰発現の意義

miR-210过表达在肾透明细胞癌中的意义

• 发表时间: 2012
• 作者: 中田 知里;塚本 善之;松浦 恵子;グエン・トゥン・ラム ;泥谷 直樹;内田智久;佐藤 文憲;三股 浩光;瀬戸 加大;守山 正胤
• 通讯作者: 守山 正胤

Genomic profiling of renal cell carcinoma in patients with end-stage renal disease

• DOI: 10.1111/j.1349-7006.2011.02176.x
• 发表时间: 2012-03-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Inoue, Toru;Matsuura, Keiko;Moriyama, Masatsugu
• 通讯作者: Moriyama, Masatsugu