Basic research for investigation of novel oncogenic mechanism by TLS-CHOP chimeric oncoprotein and its clinical application

来自染色体易位的TLS-CHOP融合基因是黏液样脂肪肉瘤特异性癌基因。然而，其在肿瘤细胞中的成瘤机制和功能尚不清楚。在这项研究中，我们发现TLS-CHOP抑制抗癌细胞因子MDA-7/IL-24的表达，并抑制靶向肿瘤细胞生长和转移激活因子PAI-1的miR-486。此外，还提出了一种诱导肿瘤发生相关蛋白PRG4表达的新分子途径。

The TLS-CHOP fusion gene derived from chromosomal translocation is myxoid liposarcoma-specific oncogene. However, its oncogenesis mechanism and functions in tumor cells are still unclear. In this study, we have revealed that TLS-CHOP represses an anticancer cytokine MDA-7/IL-24 expression, and represses miR-486 that targets a tumor cell growth and metastasis activator PAI-1 In addition, a novel molecular pathway that induces expression of a tumorigenesis-related protein PRG4 has been suggested.